Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 2430208..2430861 Replicon chromosome
Accession NZ_CP091367
Organism Acinetobacter baumannii strain AB169-VUB

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag L2Z07_RS11645 Protein ID WP_000931890.1
Coordinates 2430208..2430597 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z07_RS11650 Protein ID WP_001288210.1
Coordinates 2430604..2430861 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z07_RS11630 (L2Z07_11630) 2425326..2427521 - 2196 WP_225488236.1 TRAP transporter large permease subunit -
L2Z07_RS11635 (L2Z07_11635) 2427709..2428275 - 567 WP_000651536.1 rhombosortase -
L2Z07_RS11640 (L2Z07_11640) 2428353..2429438 - 1086 WP_000049106.1 hypothetical protein -
L2Z07_RS11645 (L2Z07_11645) 2430208..2430597 - 390 WP_000931890.1 membrane protein Toxin
L2Z07_RS11650 (L2Z07_11650) 2430604..2430861 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z07_RS11655 (L2Z07_11655) 2431049..2432221 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z07_RS11660 (L2Z07_11660) 2432271..2433761 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z07_RS11665 (L2Z07_11665) 2433940..2434317 - 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z07_RS11670 (L2Z07_11670) 2434336..2435343 - 1008 WP_226176127.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T233251 WP_000931890.1 NZ_CP091367:c2430597-2430208 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233251 NZ_HF572917:1308089-1308463 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233251 WP_001288210.1 NZ_CP091367:c2430861-2430604 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233251 NZ_HF572917:1307645-1307998 [Escherichia coli]
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References