Detailed information of TA system TA233250

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3305286..3305939
• Replicon: chromosome
• Accession: NZ_CP091366
• Organism: Acinetobacter baumannii strain AB171-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z08_RS15830
• Protein ID: WP_000607077.1
• Coordinates: 3305286..3305675 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z08_RS15835
• Protein ID: WP_001288210.1
• Coordinates: 3305682..3305939 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z08_RS15815 (L2Z08_15810)	3300404..3302599	-	2196	WP_001158909.1	TRAP transporter large permease subunit	-
L2Z08_RS15820 (L2Z08_15815)	3302787..3303353	-	567	WP_000651538.1	rhombosortase	-
L2Z08_RS15825 (L2Z08_15820)	3303431..3304516	-	1086	WP_000049106.1	hypothetical protein	-
L2Z08_RS15830 (L2Z08_15825)	3305286..3305675	-	390	WP_000607077.1	membrane protein	Toxin
L2Z08_RS15835 (L2Z08_15830)	3305682..3305939	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z08_RS15840 (L2Z08_15835)	3306127..3307299	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z08_RS15845 (L2Z08_15840)	3307348..3308838	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z08_RS15850 (L2Z08_15845)	3309019..3309396	-	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z08_RS15855 (L2Z08_15850)	3309415..3310422	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233250 WP_000607077.1 NZ_CP091366:c3305675-3305286 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233250 NZ_HF572917:c514570-514352 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233250 WP_001288210.1 NZ_CP091366:c3305939-3305682 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233250 NZ_HF572917:c514970-514596 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7