Detailed information of TA system TA233248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1820522..1821201
• Replicon: chromosome
• Accession: NZ_CP091366
• Organism: Acinetobacter baumannii strain AB171-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z08_RS08775
• Protein ID: WP_000838146.1
• Coordinates: 1821019..1821201 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: L2Z08_RS08770
• Protein ID: WP_000966688.1
• Coordinates: 1820522..1820926 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z08_RS08760 (L2Z08_08755)	1819478..1819741	-	264	WP_001275792.1	hypothetical protein	-
L2Z08_RS08765 (L2Z08_08760)	1819743..1820423	-	681	WP_000721572.1	hypothetical protein	-
L2Z08_RS08770 (L2Z08_08765)	1820522..1820926	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z08_RS08775 (L2Z08_08770)	1821019..1821201	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z08_RS08780 (L2Z08_08775)	1821527..1822042	-	516	WP_024616020.1	hypothetical protein	-
L2Z08_RS08785 (L2Z08_08780)	1822113..1823030	-	918	WP_000094253.1	phage tail tube protein	-
L2Z08_RS08790 (L2Z08_08785)	1823083..1824438	-	1356	WP_000002415.1	hypothetical protein	-
L2Z08_RS08795 (L2Z08_08790)	1824438..1824791	-	354	WP_000064593.1	hypothetical protein	-
L2Z08_RS08800 (L2Z08_08795)	1824888..1825409	-	522	WP_000749909.1	SH3 domain-containing protein	-
L2Z08_RS08805 (L2Z08_08800)	1825518..1825736	-	219	WP_001277696.1	hypothetical protein	-
L2Z08_RS08810 (L2Z08_08805)	1825738..1826181	-	444	WP_002016455.1	phage tail terminator-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1801695..1851732	50037

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233248 WP_000838146.1 NZ_CP091366:c1821201-1821019 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233248 NZ_HF572917:c277608-277330 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGAGGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT233248 WP_000966688.1 NZ_CP091366:c1820926-1820522 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233248 NZ_HF572917:c277871-277611 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6