Detailed information of TA system TA233245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1842638..1843317
• Replicon: chromosome
• Accession: NZ_CP091365
• Organism: Acinetobacter baumannii strain AB172-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z09_RS08860
• Protein ID: WP_000838146.1
• Coordinates: 1843135..1843317 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: L2Z09_RS08855
• Protein ID: WP_000966688.1
• Coordinates: 1842638..1843042 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z09_RS08845 (L2Z09_08840)	1841594..1841857	-	264	WP_001275792.1	hypothetical protein	-
L2Z09_RS08850 (L2Z09_08845)	1841859..1842539	-	681	WP_000721572.1	hypothetical protein	-
L2Z09_RS08855 (L2Z09_08850)	1842638..1843042	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z09_RS08860 (L2Z09_08855)	1843135..1843317	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z09_RS08865 (L2Z09_08860)	1843643..1844158	-	516	WP_024616020.1	hypothetical protein	-
L2Z09_RS08870 (L2Z09_08865)	1844229..1845146	-	918	WP_000094253.1	phage tail tube protein	-
L2Z09_RS08875 (L2Z09_08870)	1845199..1846554	-	1356	WP_000002415.1	hypothetical protein	-
L2Z09_RS08880 (L2Z09_08875)	1846554..1846907	-	354	WP_000064593.1	hypothetical protein	-
L2Z09_RS08885 (L2Z09_08880)	1847004..1847525	-	522	WP_000749909.1	SH3 domain-containing protein	-
L2Z09_RS08890 (L2Z09_08885)	1847634..1847852	-	219	WP_001277696.1	hypothetical protein	-
L2Z09_RS08895 (L2Z09_08890)	1847854..1848297	-	444	WP_002016455.1	phage tail terminator-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1823810..1873848	50038

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233245 WP_000838146.1 NZ_CP091365:c1843317-1843135 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233245 NZ_HF571988:c4206316-4205996 [Yersinia enterocolitica (type O:5) str. YE53/03]
ATGCATATTTCAACTGTACCGGCCACGGTGCCGGTTTCGCCACGCCTGTCGCCCGTTCAGGTCTGGCAGCAACTGTTAAC
GTACCTACTGGAACACCATTACGGTCTTACGCTAAACGACACACCATTCCATGATGATTCCGCCATCCAGGAACATATCG
AAGCGGGTATCACACTGGCTGATGCGGTGAACTTTCTGGTGGAACGCTATGAACTGATACGCACTGACCGCAAAGGGTTT
ACATGGCAAGATCAGACACCATTTCTGGCCGCTATCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATGAATATATA
A

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT233245 WP_000966688.1 NZ_CP091365:c1843042-1842638 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233245 NZ_HF571988:c4206715-4206350 [Yersinia enterocolitica (type O:5) str. YE53/03]
ATGCAATCGACCACCTTATCCGGCACATCAGCGGAGAACGCATCCTGCCTTCAGTGGGGATTAAAACGTAATATCACGCC
GTGCTTCTGCGCTCGCCTAGTACAGGAAGGCAACCGTCTCTACTTTCTGGCTGACCGGGCTGGGTTTGATGGCTCATTCA
GTGACGATGAAGCATTGCGTCTGGACCAGGTGTTTCCACTTATGATGAAACAGCTAGAGCGGATGCTCACCACTGGAGAG
CTTGATCCCCGCTGTCAGCACTGCGTCACTCTGCATCACAATGAACTCACCTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATCGCTATTTATCCCCAGTCAGCCGTAACCAGGTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6