Detailed information of TA system TA233244

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 479764..480417
• Replicon: chromosome
• Accession: NZ_CP091364
• Organism: Acinetobacter baumannii strain AB173-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z10_RS02280
• Protein ID: WP_000607077.1
• Coordinates: 479764..480153 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z10_RS02285
• Protein ID: WP_001288210.1
• Coordinates: 480160..480417 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z10_RS02265 (L2Z10_02265)	474882..477077	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
L2Z10_RS02270 (L2Z10_02270)	477265..477831	-	567	WP_000651538.1	rhombosortase	-
L2Z10_RS02275 (L2Z10_02275)	477909..478994	-	1086	WP_000049106.1	hypothetical protein	-
L2Z10_RS02280 (L2Z10_02280)	479764..480153	-	390	WP_000607077.1	membrane protein	Toxin
L2Z10_RS02285 (L2Z10_02285)	480160..480417	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z10_RS02290 (L2Z10_02290)	480605..481777	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z10_RS02295 (L2Z10_02295)	481826..483316	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z10_RS02300 (L2Z10_02300)	483498..483875	-	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z10_RS02305 (L2Z10_02305)	483894..484901	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233244 WP_000607077.1 NZ_CP091364:c480153-479764 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233244 NZ_HF571988:3582997-3583200 [Yersinia enterocolitica (type O:5) str. YE53/03]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233244 WP_001288210.1 NZ_CP091364:c480417-480160 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233244 NZ_HF571988:3582582-3582950 [Yersinia enterocolitica (type O:5) str. YE53/03]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGCGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7