Detailed information of TA system TA233243

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3068947..3069600
• Replicon: chromosome
• Accession: NZ_CP091363
• Organism: Acinetobacter baumannii strain AB175-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z11_RS14865
• Protein ID: WP_000607077.1
• Coordinates: 3069211..3069600 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z11_RS14860
• Protein ID: WP_001288210.1
• Coordinates: 3068947..3069204 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z11_RS14840 (L2Z11_14840)	3064463..3065470	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
L2Z11_RS14845 (L2Z11_14845)	3065489..3065866	+	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z11_RS14850 (L2Z11_14850)	3066048..3067538	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z11_RS14855 (L2Z11_14855)	3067587..3068759	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z11_RS14860 (L2Z11_14860)	3068947..3069204	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z11_RS14865 (L2Z11_14865)	3069211..3069600	+	390	WP_000607077.1	membrane protein	Toxin
L2Z11_RS14870 (L2Z11_14870)	3070370..3071455	+	1086	WP_000049106.1	hypothetical protein	-
L2Z11_RS14875 (L2Z11_14875)	3071533..3072099	+	567	WP_000651538.1	rhombosortase	-
L2Z11_RS14880 (L2Z11_14880)	3072287..3074482	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233243 WP_000607077.1 NZ_CP091363:3069211-3069600 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233243 NZ_HF571988:c2798304-2798026 [Yersinia enterocolitica (type O:5) str. YE53/03]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
GAATAAACTTAAAGTCATTATGACGCTTCTGATTAACGATAAATTGCCCTTGCCTGTTGTATATAAGGATCATCAATTAC
AAGGTAATTACAAAGGTTACAGGGATGCACATATAGAGCCAGACTGGCTTATCATCTACAAGATTACTGATGATTTGCTT
CGCTTCGAAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233243 WP_001288210.1 NZ_CP091363:3068947-3069204 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233243 NZ_HF571988:c2798571-2798311 [Yersinia enterocolitica (type O:5) str. YE53/03]
ATGGCTACAAATGCTTTTGTTCGTGCTCGTATAGACGAAACCCTAAAAAATGAAGCCGCTGCTGTGCTTGCAGGTATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTTGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAACTTACCGCTAATACTATTGCCAACAGCGAGAAAGGTGTCGATGTCCATAAAGCAAAGGATGCTGATGATCTT
TTTGATAAATTAGGTATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7