233241

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 933593..934272 Replicon chromosome
Accession NZ_CP091362
Organism Acinetobacter baumannii strain AB176-VUB

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag L2Z12_RS04415 Protein ID WP_000838146.1
Coordinates 934090..934272 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag L2Z12_RS04410 Protein ID WP_000966688.1
Coordinates 933593..933997 (-) Length 135 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z12_RS04375 (L2Z12_04370) 928886..929401 - 516 WP_001056868.1 Rha family transcriptional regulator -
L2Z12_RS04380 (L2Z12_04375) 929742..930677 - 936 WP_000254125.1 ORF6N domain-containing protein -
L2Z12_RS04385 (L2Z12_04380) 930827..931093 + 267 WP_000774879.1 hypothetical protein -
L2Z12_RS04390 (L2Z12_04385) 931136..931627 - 492 WP_000755583.1 DUF4468 domain-containing protein -
L2Z12_RS04395 (L2Z12_04390) 931713..932459 - 747 WP_000599537.1 hypothetical protein -
L2Z12_RS04400 (L2Z12_04395) 932521..932904 - 384 WP_000725052.1 hypothetical protein -
L2Z12_RS04405 (L2Z12_04400) 932969..933493 - 525 WP_000721574.1 DUF4468 domain-containing protein -
L2Z12_RS04410 (L2Z12_04405) 933593..933997 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L2Z12_RS04415 (L2Z12_04410) 934090..934272 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
L2Z12_RS04420 (L2Z12_04415) 934598..935113 - 516 WP_138147038.1 hypothetical protein -
L2Z12_RS04425 (L2Z12_04420) 935183..936100 - 918 WP_000094273.1 phage tail tube protein -
L2Z12_RS04430 (L2Z12_04425) 936153..937457 - 1305 WP_032038814.1 pyocin knob domain-containing protein -
L2Z12_RS04435 (L2Z12_04430) 937457..937810 - 354 WP_000064603.1 hypothetical protein -
L2Z12_RS04440 (L2Z12_04435) 937907..938428 - 522 WP_215748175.1 SH3 domain-containing protein -
L2Z12_RS04445 (L2Z12_04440) 938537..938755 - 219 WP_001277696.1 hypothetical protein -
L2Z12_RS04450 (L2Z12_04445) 938757..939200 - 444 WP_002016455.1 phage tail terminator-like protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage blaADC-25 basJ / basI / basI / basH / barB / barA / basG / basF / entE / basD / basC / bauA / bauB / bauE 916500..1008084 91584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T233241 WP_000838146.1 NZ_CP091362:c934272-934090 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T233241 NZ_HF571988:2133003-2133097 [Yersinia enterocolitica (type O:5) str. YE53/03]
AACAAGCCTACGTTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATCGT
ATTCGGTCTATTTTT

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT233241 WP_000966688.1 NZ_CP091362:c933997-933593 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT233241 NZ_HF571988:c2133098-2132981 [Yersinia enterocolitica (type O:5) str. YE53/03]
TAAAAATAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAACGTAGGCTTGTTCAGCCATACTCTTTAAGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S3TWT7


Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References