Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1022327..1023006 Replicon chromosome
Accession NZ_CP091361
Organism Acinetobacter baumannii strain AB177-VUB

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag L2Z13_RS05005 Protein ID WP_000838146.1
Coordinates 1022824..1023006 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag L2Z13_RS05000 Protein ID WP_000966688.1
Coordinates 1022327..1022731 (-) Length 135 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z13_RS04960 (L2Z13_04960) 1017366..1017713 - 348 WP_057078074.1 hypothetical protein -
L2Z13_RS04965 (L2Z13_04965) 1017837..1018346 - 510 WP_057078075.1 Rha family transcriptional regulator -
L2Z13_RS04970 (L2Z13_04970) 1018482..1019411 - 930 WP_057078076.1 ORF6N domain-containing protein -
L2Z13_RS04975 (L2Z13_04975) 1019561..1019827 + 267 WP_000774879.1 hypothetical protein -
L2Z13_RS04980 (L2Z13_04980) 1019870..1020361 - 492 WP_000755583.1 DUF4468 domain-containing protein -
L2Z13_RS04985 (L2Z13_04985) 1020447..1021193 - 747 WP_000599537.1 hypothetical protein -
L2Z13_RS04990 (L2Z13_04990) 1021255..1021638 - 384 WP_000725052.1 hypothetical protein -
L2Z13_RS04995 (L2Z13_04995) 1021703..1022227 - 525 WP_000721574.1 DUF4468 domain-containing protein -
L2Z13_RS05000 (L2Z13_05000) 1022327..1022731 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L2Z13_RS05005 (L2Z13_05005) 1022824..1023006 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
L2Z13_RS05010 (L2Z13_05010) 1023075..1023404 - 330 WP_079289049.1 hypothetical protein -
L2Z13_RS05015 (L2Z13_05015) 1023332..1023847 - 516 WP_084055044.1 hypothetical protein -
L2Z13_RS05020 (L2Z13_05020) 1023917..1024834 - 918 WP_084055043.1 phage tail tube protein -
L2Z13_RS05025 (L2Z13_05025) 1024887..1025873 - 987 WP_084055042.1 phage tail protein -
L2Z13_RS05030 (L2Z13_05030) 1025873..1026223 - 351 WP_057078079.1 hypothetical protein -
L2Z13_RS05035 (L2Z13_05035) 1026305..1026589 - 285 WP_057078080.1 hypothetical protein -
L2Z13_RS05040 (L2Z13_05040) 1026637..1027035 - 399 WP_057078081.1 hypothetical protein -
L2Z13_RS05045 (L2Z13_05045) 1027037..1027405 - 369 WP_057078082.1 hypothetical protein -
L2Z13_RS05050 (L2Z13_05050) 1027377..1027784 - 408 WP_049592426.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1002297..1056299 54002


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T233239 WP_000838146.1 NZ_CP091361:c1023006-1022824 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T233239 NZ_HF571988:930925-931248 [Yersinia enterocolitica (type O:5) str. YE53/03]
ATGAAAATTCTACCGGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGCCACCCGTTGCAGTCTGGCAATTGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCAGTGATGAAACCGTTATAAAGGAACATTTCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGAATATTGATATCATGAGGGCCCGCCGCGATCTGGGTTTATTAAATCGTAA
TTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT233239 WP_000966688.1 NZ_CP091361:c1022731-1022327 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT233239 NZ_HF571988:930587-930904 [Yersinia enterocolitica (type O:5) str. YE53/03]
ATGAGCAACATCATTTGGGGCCTGCAGCGCGATATCACGCCGCGCCTGGGAACACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTACCTGGCTGACCGGGCCTGTATCACAGGTAAGTTCAGTGATGCCGAATGTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCCGGATGGAATCCATGCTGAGCACGGGTGAAATGAATCCTCGCCACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGTGGCTATGTATACGTCGCTGTTTATTCCACTCAGCGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S3TWT7


Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References