Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 957430..958014 | Replicon | chromosome |
| Accession | NZ_CP091361 | ||
| Organism | Acinetobacter baumannii strain AB177-VUB | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | N8Q7V3 |
| Locus tag | L2Z13_RS04695 | Protein ID | WP_000286964.1 |
| Coordinates | 957430..957732 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | L2Z13_RS04700 | Protein ID | WP_000985609.1 |
| Coordinates | 957733..958014 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2Z13_RS04655 (L2Z13_04655) | 952462..952764 | + | 303 | WP_000251875.1 | phosphoglucosamine mutase | - |
| L2Z13_RS04660 (L2Z13_04660) | 952940..953770 | - | 831 | Protein_930 | IS91-like element ISVsa3 family transposase | - |
| L2Z13_RS04665 (L2Z13_04665) | 953834..954538 | + | 705 | WP_071543226.1 | IS6-like element IS1006 family transposase | - |
| L2Z13_RS04670 (L2Z13_04670) | 954666..955004 | - | 339 | WP_032073153.1 | hypothetical protein | - |
| L2Z13_RS04675 (L2Z13_04675) | 955063..955833 | + | 771 | WP_032073134.1 | hypothetical protein | - |
| L2Z13_RS04680 (L2Z13_04680) | 955894..956208 | - | 315 | WP_004728120.1 | BrnA antitoxin family protein | - |
| L2Z13_RS04685 (L2Z13_04685) | 956195..956482 | - | 288 | WP_000438825.1 | BrnT family toxin | - |
| L2Z13_RS04690 (L2Z13_04690) | 956751..957281 | - | 531 | WP_000172759.1 | hypothetical protein | - |
| L2Z13_RS04695 (L2Z13_04695) | 957430..957732 | + | 303 | WP_000286964.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L2Z13_RS04700 (L2Z13_04700) | 957733..958014 | + | 282 | WP_000985609.1 | putative addiction module antidote protein | Antitoxin |
| L2Z13_RS04705 (L2Z13_04705) | 958094..958513 | - | 420 | WP_001180106.1 | SMI1/KNR4 family protein | - |
| L2Z13_RS04710 (L2Z13_04710) | 958676..960010 | + | 1335 | WP_033917544.1 | ISNCY family transposase | - |
| L2Z13_RS04715 (L2Z13_04715) | 960139..960459 | + | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| L2Z13_RS04720 (L2Z13_04720) | 960452..960724 | + | 273 | WP_000369781.1 | NadS family protein | - |
| L2Z13_RS04725 (L2Z13_04725) | 961217..962692 | + | 1476 | WP_000052512.1 | ABC-F type ribosomal protection protein Msr(E) | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | sul2 | - | 947201..960010 | 12809 | |
| - | inside | IScluster/Tn | sul2 / msr(E) / mph(E) / blaADC-25 | - | 950340..969147 | 18807 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11573.07 Da Isoelectric Point: 4.6838
>T233237 WP_000286964.1 NZ_CP091361:957430-957732 [Acinetobacter baumannii]
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
Download Length: 303 bp
>T233237 NZ_HF545616:1886040-1886222 [Ruminococcus bicirculans]
ATGACGTTCAAAGAAATGGATAGGCTACTTAAAGAAGCTGGATGGTATTATGACGGTGCAAGAGGTTCTCACTTCAAATA
TAAACATAAGAGTCAAAATGGAATCGTCATTGTTCCCAACCACAAAGGAGATATTCCAAAAGGAACGGCAAACGCAATTT
TAAAACAGGCAGGGCTTAAATAA
ATGACGTTCAAAGAAATGGATAGGCTACTTAAAGAAGCTGGATGGTATTATGACGGTGCAAGAGGTTCTCACTTCAAATA
TAAACATAAGAGTCAAAATGGAATCGTCATTGTTCCCAACCACAAAGGAGATATTCCAAAAGGAACGGCAAACGCAATTT
TAAAACAGGCAGGGCTTAAATAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10109.67 Da Isoelectric Point: 8.0018
>AT233237 WP_000985609.1 NZ_CP091361:957733-958014 [Acinetobacter baumannii]
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
Download Length: 282 bp
>AT233237 NZ_HF545616:1886259-1886669 [Ruminococcus bicirculans]
ATGTTATCAATGTATCCGGCTTGTTTTTACAAAGAAAAAGAAGGTGGCTATTCTGTCATATTTCCTGTTCTCGGAATTGC
CACTTGCGGCGATGACATCAATCAAGCTATGAGTATGGCAGTTGATTGCCTTGCCGGTTATTTGTATGAGTTAAAACTCA
GCAAAGAAGAAGTTCCTGCTGCACCTGATATGGATAAGATCGACATCGATGCAGAATATAACGATTATGAAAGTGCTTTT
GTAAATATGGTGACCGTCGATGTTGATGAGTATGCGAAAAAGCACTTTGAAAAGTCTGTCAAGAAAACTTTGACCATTCC
CTCCTGGTTAAATGAACTTGCTGTTGCCAACGGCATAAATTTTTCGCAAGTTCTTCAGACTGCTCTTAAGGATAAGCTCA
ATGTGAATTAA
ATGTTATCAATGTATCCGGCTTGTTTTTACAAAGAAAAAGAAGGTGGCTATTCTGTCATATTTCCTGTTCTCGGAATTGC
CACTTGCGGCGATGACATCAATCAAGCTATGAGTATGGCAGTTGATTGCCTTGCCGGTTATTTGTATGAGTTAAAACTCA
GCAAAGAAGAAGTTCCTGCTGCACCTGATATGGATAAGATCGACATCGATGCAGAATATAACGATTATGAAAGTGCTTTT
GTAAATATGGTGACCGTCGATGTTGATGAGTATGCGAAAAAGCACTTTGAAAAGTCTGTCAAGAAAACTTTGACCATTCC
CTCCTGGTTAAATGAACTTGCTGTTGCCAACGGCATAAATTTTTCGCAAGTTCTTCAGACTGCTCTTAAGGATAAGCTCA
ATGTGAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|