Detailed information of TA system TA233235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 60267..60946
• Replicon: chromosome
• Accession: NZ_CP091361
• Organism: Acinetobacter baumannii strain AB177-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z13_RS00380
• Protein ID: WP_000838146.1
• Coordinates: 60267..60449 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: L2Z13_RS00385
• Protein ID: WP_000966688.1
• Coordinates: 60542..60946 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z13_RS00345 (L2Z13_00345)	55565..55933	+	369	WP_025468552.1	hypothetical protein	-
L2Z13_RS00350 (L2Z13_00350)	55935..56333	+	399	WP_057078255.1	phage tail terminator-like protein	-
L2Z13_RS00355 (L2Z13_00355)	56335..56562	+	228	WP_057078256.1	hypothetical protein	-
L2Z13_RS00360 (L2Z13_00360)	56677..57030	+	354	WP_057078257.1	hypothetical protein	-
L2Z13_RS00365 (L2Z13_00365)	57030..58385	+	1356	WP_000002416.1	hypothetical protein	-
L2Z13_RS00370 (L2Z13_00370)	58438..59355	+	918	WP_000094253.1	phage tail tube protein	-
L2Z13_RS00375 (L2Z13_00375)	59426..59941	+	516	WP_024616020.1	hypothetical protein	-
L2Z13_RS00380 (L2Z13_00380)	60267..60449	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z13_RS00385 (L2Z13_00385)	60542..60946	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z13_RS00390 (L2Z13_00390)	61045..61725	+	681	WP_000721572.1	hypothetical protein	-
L2Z13_RS00395 (L2Z13_00395)	61727..61990	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	26111..79903	53792

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233235 WP_000838146.1 NZ_CP091361:60267-60449 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233235 NZ_FWEX01000005:c408592-408341 [Nitrospira sp. ND1]
ATGGATGCGATCACCTACACTGCCGTTCGCGCAAACCTTGCAAGCGCCATGGACCGCGTGTGCGACGACCATGAAGCCTT
GATCATTACTCGCAACGGAGAACAGTCCGTCGTCATGCTCTCGCTCGAAGACTACAAGGCGCTTGAAGAAACCGCCTATC
TCTTGCGCACCCCCGCCAATGCCACACGTCTGCTTGCTGCCGCGGCACAGCTGAACGCCGGCAAAGGGGTTCAGCGGAAG
TTGGCCAAGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT233235 WP_000966688.1 NZ_CP091361:60542-60946 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233235 NZ_FWEX01000005:c408344-408090 [Nitrospira sp. ND1]
GTGAAGCTGATCTTCGCCGAGGAGGCCTGGGAAGATTATCTGTACTGGCTACAGCAAGACAGGCGCATGGTCGAGCGAAT
CAACAAGCTGATACGCGAGACACAGCGTCAGCCATTCGCGGGCATGGGCAAGCCTGAACCATTGAAGCATGCGCTTTCAG
GATTCTGGTCGCGCCGAATAACCGATGAACATCGCATGGTGTACCGCGTCGAGAGTGATGCTCTGATGATCGCTCAGCTG
CGTTTCCATTACTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6