Detailed information of TA system TA233234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2486400..2487079
• Replicon: chromosome
• Accession: NZ_CP091360
• Organism: Acinetobacter baumannii strain AB179-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: L2Z14_RS11915
• Protein ID: WP_002077557.1
• Coordinates: 2486897..2487079 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L2Z14_RS11910
• Protein ID: WP_109123209.1
• Coordinates: 2486400..2486804 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z14_RS11905 (L2Z14_11905)	2485942..2486319	-	378	WP_226200244.1	hypothetical protein	-
L2Z14_RS11910 (L2Z14_11910)	2486400..2486804	-	405	WP_109123209.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z14_RS11915 (L2Z14_11915)	2486897..2487079	-	183	WP_002077557.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z14_RS11920 (L2Z14_11920)	2487404..2487913	-	510	WP_226200246.1	hypothetical protein	-
L2Z14_RS11925 (L2Z14_11925)	2488203..2488421	-	219	WP_104130828.1	hypothetical protein	-
L2Z14_RS11930 (L2Z14_11930)	2488492..2488731	-	240	WP_045544366.1	hypothetical protein	-
L2Z14_RS11935 (L2Z14_11935)	2488877..2489533	-	657	WP_240368554.1	hypothetical protein	-
L2Z14_RS11940 (L2Z14_11940)	2489467..2489652	-	186	WP_240368555.1	hypothetical protein	-
L2Z14_RS11945 (L2Z14_11945)	2489676..2490074	-	399	WP_001019813.1	antiterminator Q family protein	-
L2Z14_RS11950 (L2Z14_11950)	2490074..2490475	-	402	WP_104130829.1	DUF559 domain-containing protein	-
L2Z14_RS11955 (L2Z14_11955)	2490475..2490699	-	225	WP_001288422.1	hypothetical protein	-
L2Z14_RS11960 (L2Z14_11960)	2490692..2491114	-	423	WP_001143180.1	hypothetical protein	-
L2Z14_RS11965 (L2Z14_11965)	2491104..2491526	-	423	WP_114889960.1	hypothetical protein	-
L2Z14_RS11970 (L2Z14_11970)	2491513..2491647	-	135	WP_001031752.1	putative phage replication protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2467760..2502486	34726

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6709.86 Da
• Isoelectric Point: 10.5523

>T233234 WP_002077557.1 NZ_CP091360:c2487079-2486897 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVTGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233234 NZ_FWEX01000005:c408344-408090 [Nitrospira sp. ND1]
GTGAAGCTGATCTTCGCCGAGGAGGCCTGGGAAGATTATCTGTACTGGCTACAGCAAGACAGGCGCATGGTCGAGCGAAT
CAACAAGCTGATACGCGAGACACAGCGTCAGCCATTCGCGGGCATGGGCAAGCCTGAACCATTGAAGCATGCGCTTTCAG
GATTCTGGTCGCGCCGAATAACCGATGAACATCGCATGGTGTACCGCGTCGAGAGTGATGCTCTGATGATCGCTCAGCTG
CGTTTCCATTACTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14661.72 Da
• Isoelectric Point: 4.4328

>AT233234 WP_109123209.1 NZ_CP091360:c2486804-2486400 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFIDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233234 NZ_FWEX01000005:c408592-408341 [Nitrospira sp. ND1]
ATGGATGCGATCACCTACACTGCCGTTCGCGCAAACCTTGCAAGCGCCATGGACCGCGTGTGCGACGACCATGAAGCCTT
GATCATTACTCGCAACGGAGAACAGTCCGTCGTCATGCTCTCGCTCGAAGACTACAAGGCGCTTGAAGAAACCGCCTATC
TCTTGCGCACCCCCGCCAATGCCACACGTCTGCTTGCTGCCGCGGCACAGCTGAACGCCGGCAAAGGGGTTCAGCGGAAG
TTGGCCAAGTGA