Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 789861..790514 Replicon chromosome
Accession NZ_CP091360
Organism Acinetobacter baumannii strain AB179-VUB

Toxin (Protein)


Gene name cptA Uniprot ID A0A5N0FZY3
Locus tag L2Z14_RS03905 Protein ID WP_000607074.1
Coordinates 790125..790514 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z14_RS03900 Protein ID WP_001288210.1
Coordinates 789861..790118 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z14_RS03880 (L2Z14_03880) 785378..786385 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
L2Z14_RS03885 (L2Z14_03885) 786404..786781 + 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z14_RS03890 (L2Z14_03890) 786961..788451 + 1491 WP_000415136.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z14_RS03895 (L2Z14_03895) 788501..789673 - 1173 WP_001190545.1 acyl-CoA dehydrogenase family protein -
L2Z14_RS03900 (L2Z14_03900) 789861..790118 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z14_RS03905 (L2Z14_03905) 790125..790514 + 390 WP_000607074.1 membrane protein Toxin
L2Z14_RS03910 (L2Z14_03910) 791284..792369 + 1086 WP_000049106.1 hypothetical protein -
L2Z14_RS03915 (L2Z14_03915) 792447..793013 + 567 WP_000651536.1 rhombosortase -
L2Z14_RS03920 (L2Z14_03920) 793201..795396 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15621.89 Da        Isoelectric Point: 10.3890

>T233232 WP_000607074.1 NZ_CP091360:790125-790514 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233232 NZ_FO834906:c5106574-5106290 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233232 WP_001288210.1 NZ_CP091360:789861-790118 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233232 NZ_FO834906:c5106806-5106564 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5N0FZY3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References