Detailed information of TA system TA233231

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3436697..3437350
• Replicon: chromosome
• Accession: NZ_CP091359
• Organism: Acinetobacter baumannii strain AB180-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z16_RS16395
• Protein ID: WP_000607077.1
• Coordinates: 3436697..3437086 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z16_RS16400
• Protein ID: WP_001288210.1
• Coordinates: 3437093..3437350 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z16_RS16380 (L2Z16_16380)	3431815..3434010	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
L2Z16_RS16385 (L2Z16_16385)	3434198..3434764	-	567	WP_000651538.1	rhombosortase	-
L2Z16_RS16390 (L2Z16_16390)	3434842..3435927	-	1086	WP_000049106.1	hypothetical protein	-
L2Z16_RS16395 (L2Z16_16395)	3436697..3437086	-	390	WP_000607077.1	membrane protein	Toxin
L2Z16_RS16400 (L2Z16_16400)	3437093..3437350	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z16_RS16405 (L2Z16_16405)	3437538..3438710	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z16_RS16410 (L2Z16_16410)	3438759..3440249	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z16_RS16415 (L2Z16_16415)	3440431..3440808	-	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z16_RS16420 (L2Z16_16420)	3440827..3441834	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233231 WP_000607077.1 NZ_CP091359:c3437086-3436697 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233231 NZ_FO834906:c5006439-5005906 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGACTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233231 WP_001288210.1 NZ_CP091359:c3437350-3437093 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233231 NZ_FO834906:c5006716-5006450 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7