Detailed information of TA system TA233230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1280148..1280799
• Replicon: chromosome
• Accession: NZ_CP091358
• Organism: Acinetobacter baumannii strain AB181-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z17_RS06135
• Protein ID: WP_000838146.1
• Coordinates: 1280148..1280330 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: L2Z17_RS06140
• Protein ID: WP_000966689.1
• Coordinates: 1280395..1280799 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z17_RS06090 (L2Z17_06090)	1275404..1276069	+	666	WP_000767881.1	Ish1 domain-containing protein	-
L2Z17_RS06095 (L2Z17_06095)	1276074..1276463	+	390	WP_032041498.1	hypothetical protein	-
L2Z17_RS06100 (L2Z17_06100)	1276465..1276833	+	369	WP_000524231.1	hypothetical protein	-
L2Z17_RS06105 (L2Z17_06105)	1276842..1277246	+	405	WP_000248324.1	hypothetical protein	-
L2Z17_RS06110 (L2Z17_06110)	1277218..1277586	+	369	WP_000539752.1	hypothetical protein	-
L2Z17_RS06115 (L2Z17_06115)	1277588..1277986	+	399	WP_001132270.1	hypothetical protein	-
L2Z17_RS06120 (L2Z17_06120)	1277988..1278200	+	213	WP_000121166.1	hypothetical protein	-
L2Z17_RS06125 (L2Z17_06125)	1278309..1279238	+	930	WP_000094300.1	phage tail tube protein	-
L2Z17_RS06130 (L2Z17_06130)	1279283..1279816	+	534	WP_001185622.1	hypothetical protein	-
L2Z17_RS06135 (L2Z17_06135)	1280148..1280330	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z17_RS06140 (L2Z17_06140)	1280395..1280799	+	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z17_RS06145 (L2Z17_06145)	1280895..1281413	+	519	WP_053530939.1	DUF4468 domain-containing protein	-
L2Z17_RS06150 (L2Z17_06150)	1281510..1285478	+	3969	WP_000191303.1	tape measure protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1251284..1300726	49442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233230 WP_000838146.1 NZ_CP091358:1280148-1280330 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233230 NZ_FO834906:c4977047-4976664 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT233230 WP_000966689.1 NZ_CP091358:1280395-1280799 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233230 NZ_FO834906:c4977289-4977047 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8