Detailed information of TA system TA233228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3830682..3831361
• Replicon: chromosome
• Accession: NZ_CP091357
• Organism: Acinetobacter baumannii strain AB183-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z18_RS18475
• Protein ID: WP_000838146.1
• Coordinates: 3830682..3830864 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: L2Z18_RS18480
• Protein ID: WP_000966688.1
• Coordinates: 3830957..3831361 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z18_RS18435 (L2Z18_18435)	3825832..3826236	+	405	WP_000247952.1	hypothetical protein	-
L2Z18_RS18440 (L2Z18_18440)	3826208..3826576	+	369	WP_001993865.1	hypothetical protein	-
L2Z18_RS18445 (L2Z18_18445)	3826578..3826976	+	399	WP_002062850.1	phage tail terminator-like protein	-
L2Z18_RS18450 (L2Z18_18450)	3826978..3827196	+	219	WP_002002228.1	hypothetical protein	-
L2Z18_RS18455 (L2Z18_18455)	3827292..3827645	+	354	WP_032051762.1	hypothetical protein	-
L2Z18_RS18460 (L2Z18_18460)	3827645..3828801	+	1157	Protein_3604	phage tail protein	-
L2Z18_RS18465 (L2Z18_18465)	3828854..3829771	+	918	WP_000094273.1	phage tail tube protein	-
L2Z18_RS18470 (L2Z18_18470)	3829841..3830356	+	516	WP_001185592.1	hypothetical protein	-
L2Z18_RS18475 (L2Z18_18475)	3830682..3830864	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z18_RS18480 (L2Z18_18480)	3830957..3831361	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z18_RS18485 (L2Z18_18485)	3831461..3831985	+	525	WP_000721574.1	DUF4468 domain-containing protein	-
L2Z18_RS18490 (L2Z18_18490)	3832050..3832433	+	384	WP_000725052.1	hypothetical protein	-
L2Z18_RS18495 (L2Z18_18495)	3832495..3833241	+	747	WP_000599537.1	hypothetical protein	-
L2Z18_RS18500 (L2Z18_18500)	3833327..3833818	+	492	WP_000755583.1	DUF4468 domain-containing protein	-
L2Z18_RS18505 (L2Z18_18505)	3833861..3834127	-	267	WP_000774879.1	hypothetical protein	-
L2Z18_RS18510 (L2Z18_18510)	3834277..3835212	+	936	WP_000254125.1	ORF6N domain-containing protein	-
L2Z18_RS18515 (L2Z18_18515)	3835553..3836068	+	516	WP_001056868.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3799166..3850275	51109

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233228 WP_000838146.1 NZ_CP091357:3830682-3830864 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233228 NZ_FO834906:2884253-2885575 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCAAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT233228 WP_000966688.1 NZ_CP091357:3830957-3831361 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233228 NZ_FO834906:2883987-2884253 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6