Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3082478..3083131 Replicon chromosome
Accession NZ_CP091357
Organism Acinetobacter baumannii strain AB183-VUB

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag L2Z18_RS14980 Protein ID WP_000607077.1
Coordinates 3082742..3083131 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z18_RS14975 Protein ID WP_001288210.1
Coordinates 3082478..3082735 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z18_RS14955 (L2Z18_14955) 3077994..3079001 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
L2Z18_RS14960 (L2Z18_14960) 3079020..3079397 + 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z18_RS14965 (L2Z18_14965) 3079579..3081069 + 1491 WP_000415125.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z18_RS14970 (L2Z18_14970) 3081118..3082290 - 1173 WP_001190542.1 acyl-CoA dehydrogenase family protein -
L2Z18_RS14975 (L2Z18_14975) 3082478..3082735 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z18_RS14980 (L2Z18_14980) 3082742..3083131 + 390 WP_000607077.1 membrane protein Toxin
L2Z18_RS14985 (L2Z18_14985) 3083901..3084986 + 1086 WP_000049106.1 hypothetical protein -
L2Z18_RS14990 (L2Z18_14990) 3085064..3085630 + 567 WP_000651538.1 rhombosortase -
L2Z18_RS14995 (L2Z18_14995) 3085818..3088013 + 2196 WP_001158906.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T233227 WP_000607077.1 NZ_CP091357:3082742-3083131 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233227 NZ_FO834906:c1457998-1457780 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233227 WP_001288210.1 NZ_CP091357:3082478-3082735 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233227 NZ_FO834906:c1458399-1458025 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References