Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 3014020..3014604 | Replicon | chromosome |
| Accession | NZ_CP091356 | ||
| Organism | Acinetobacter baumannii strain AB186-VUB | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | N8Q7V3 |
| Locus tag | L2Z19_RS14340 | Protein ID | WP_000286964.1 |
| Coordinates | 3014302..3014604 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | L2Z19_RS14335 | Protein ID | WP_000985609.1 |
| Coordinates | 3014020..3014301 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2Z19_RS14310 (L2Z19_14295) | 3009342..3010817 | - | 1476 | WP_000052512.1 | ABC-F type ribosomal protection protein Msr(E) | - |
| L2Z19_RS14315 (L2Z19_14300) | 3011310..3011582 | - | 273 | WP_000369781.1 | NadS family protein | - |
| L2Z19_RS14320 (L2Z19_14305) | 3011575..3011895 | - | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| L2Z19_RS14325 (L2Z19_14310) | 3012024..3013358 | - | 1335 | WP_033917544.1 | ISNCY family transposase | - |
| L2Z19_RS14330 (L2Z19_14315) | 3013521..3013940 | + | 420 | WP_001180106.1 | SMI1/KNR4 family protein | - |
| L2Z19_RS14335 (L2Z19_14320) | 3014020..3014301 | - | 282 | WP_000985609.1 | putative addiction module antidote protein | Antitoxin |
| L2Z19_RS14340 (L2Z19_14325) | 3014302..3014604 | - | 303 | WP_000286964.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L2Z19_RS14345 (L2Z19_14330) | 3014753..3015283 | + | 531 | WP_000172759.1 | hypothetical protein | - |
| L2Z19_RS14350 (L2Z19_14335) | 3015552..3015839 | + | 288 | WP_000438825.1 | BrnT family toxin | - |
| L2Z19_RS14355 (L2Z19_14340) | 3015826..3016140 | + | 315 | WP_004728120.1 | BrnA antitoxin family protein | - |
| L2Z19_RS14360 (L2Z19_14345) | 3016201..3016971 | - | 771 | WP_032073134.1 | hypothetical protein | - |
| L2Z19_RS14365 (L2Z19_14350) | 3017030..3017368 | + | 339 | WP_032073153.1 | hypothetical protein | - |
| L2Z19_RS14370 (L2Z19_14355) | 3017496..3018200 | - | 705 | WP_071543226.1 | IS6-like element IS1006 family transposase | - |
| L2Z19_RS14375 (L2Z19_14360) | 3018264..3019094 | + | 831 | Protein_2781 | IS91-like element ISVsa3 family transposase | - |
| L2Z19_RS14380 (L2Z19_14365) | 3019270..3019572 | - | 303 | WP_000251875.1 | phosphoglucosamine mutase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | sul2 | - | 3012024..3020962 | 8938 | |
| - | inside | IScluster/Tn | blaADC-25 / mph(E) / msr(E) / sul2 | - | 3002887..3021694 | 18807 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11573.07 Da Isoelectric Point: 4.6838
>T233225 WP_000286964.1 NZ_CP091356:c3014604-3014302 [Acinetobacter baumannii]
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
Download Length: 303 bp
>T233225 NZ_FO834906:721375-721860 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAATCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA
ATGATCTTGGCACCAGAATCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10109.67 Da Isoelectric Point: 8.0018
>AT233225 WP_000985609.1 NZ_CP091356:c3014301-3014020 [Acinetobacter baumannii]
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
Download Length: 282 bp
>AT233225 NZ_FO834906:721085-721378 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|