Detailed information of TA system TA233223

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2281496..2282149
• Replicon: chromosome
• Accession: NZ_CP091356
• Organism: Acinetobacter baumannii strain AB186-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A9E9PBS3
• Locus tag: L2Z19_RS11050
• Protein ID: WP_002096593.1
• Coordinates: 2281760..2282149 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2G8V6F0
• Locus tag: L2Z19_RS11045
• Protein ID: WP_029424136.1
• Coordinates: 2281496..2281753 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z19_RS11025 (L2Z19_11015)	2277012..2278019	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
L2Z19_RS11030 (L2Z19_11020)	2278038..2278415	+	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z19_RS11035 (L2Z19_11025)	2278597..2280087	+	1491	WP_000415132.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z19_RS11040 (L2Z19_11030)	2280136..2281308	-	1173	WP_001190550.1	acyl-CoA dehydrogenase family protein	-
L2Z19_RS11045 (L2Z19_11035)	2281496..2281753	+	258	WP_029424136.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z19_RS11050 (L2Z19_11040)	2281760..2282149	+	390	WP_002096593.1	hypothetical protein	Toxin
L2Z19_RS11055 (L2Z19_11045)	2282919..2284004	+	1086	WP_000049106.1	hypothetical protein	-
L2Z19_RS11060 (L2Z19_11050)	2284082..2284648	+	567	WP_000651536.1	rhombosortase	-
L2Z19_RS11065 (L2Z19_11055)	2284836..2287031	+	2196	WP_215752880.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15677.99 Da
• Isoelectric Point: 10.3890

>T233223 WP_002096593.1 NZ_CP091356:2281760-2282149 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233223 NZ_FO834906:332561-332929 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GCCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10360.85 Da
• Isoelectric Point: 4.4909

>AT233223 WP_029424136.1 NZ_CP091356:2281496-2281753 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADLAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
YYVHG

Nucleotide

• Length: 258 bp

>AT233223 NZ_FO834906:332343-332564 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2G8V6F0