Detailed information of TA system TA233222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 8539..9218
• Replicon: chromosome
• Accession: NZ_CP091356
• Organism: Acinetobacter baumannii strain AB186-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z19_RS00055
• Protein ID: WP_000838146.1
• Coordinates: 9036..9218 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: L2Z19_RS00050
• Protein ID: WP_000966688.1
• Coordinates: 8539..8943 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z19_RS00040 (L2Z19_00040)	7495..7758	-	264	WP_001275792.1	hypothetical protein	-
L2Z19_RS00045 (L2Z19_00045)	7760..8440	-	681	WP_000721572.1	hypothetical protein	-
L2Z19_RS00050 (L2Z19_00050)	8539..8943	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z19_RS00055 (L2Z19_00055)	9036..9218	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z19_RS00060 (L2Z19_00060)	9544..10059	-	516	WP_024616020.1	hypothetical protein	-
L2Z19_RS00065 (L2Z19_00065)	10130..11047	-	918	WP_000094253.1	phage tail tube protein	-
L2Z19_RS00070 (L2Z19_00070)	11100..12455	-	1356	WP_000002416.1	hypothetical protein	-
L2Z19_RS00075 (L2Z19_00075)	12455..12808	-	354	WP_057078257.1	hypothetical protein	-
L2Z19_RS00080 (L2Z19_00080)	12923..13150	-	228	WP_057078256.1	hypothetical protein	-
L2Z19_RS00085 (L2Z19_00085)	13152..13550	-	399	WP_057078255.1	phage tail terminator-like protein	-
L2Z19_RS00090 (L2Z19_00090)	13552..13920	-	369	WP_025468552.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	plc / pgaD / pgaC / pgaB / csuE / csuD / csuC / csuB / csuA / csuA/B	210..287726	287516

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233222 WP_000838146.1 NZ_CP091356:c9218-9036 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233222 NZ_FO834905:c109868-109386 [Klebsiella pneumoniae]
ATGGGAATGAGGCCTCCGGAACCTCTTACCCCTGAACACAACATTGCTGAGTTTTGTTGTCAGGATCAGGTTCTTTCTGA
GTGGTTGAAGAAAAAGGCGCTGAAGAATCACAGAACGGGCATTTCAAGAGTTTTCGTCGTCTGTGCTGAAAACACGAATA
GGGTAATTGCGTACTACTGTTTGGCATCCGGAAGCGTGCACAGAAACACCGTACCTGGAGCATACCGTCGTAATGCACCA
GAGGCTTTACCGGTCATTGTTCTGGGAAGGCTTGCGGTTGACGCTGCCTGGGCAAGAAAAGGGCTAGGAGCTGCGCTGCT
TAAGGATGCGATATACCGAACAGAACATATTGCAATACAGGTTGGTGTTAGGGCGCTTCTTGTTCACGCCTTAAATGATG
AAGTTAGGGAATTTTACACAAAGTTTGGATTCGAGCCCTCCATTGCCAATGCGCTGACATTATTATTTCCGATCAAAACA
TGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT233222 WP_000966688.1 NZ_CP091356:c8943-8539 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233222 NZ_FO834905:c110137-109859 [Klebsiella pneumoniae]
ATGAAACCAGACATTCGTGAGGCTCCGATAAACATCCGGGCGAAAACATCTCAACGCGATCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCACGTACTGATTTTATGCTGGAAGTGGCCTGCCGCGAAGCGCAGGACATCTTGTTAGATCAGCGCT
TGTTTCTGCTGGATGATAATCAGTTTAACGCGTTTGTCGAAGAGCTTGACGCCCCTATGACCCCAGAGCGTCAGGCGCGT
ATTGATAACCTGATGAGCCGCAAATCGCCATGGGAATGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6