Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3197617..3198270 Replicon chromosome
Accession NZ_CP091355
Organism Acinetobacter baumannii strain AB187-VUB

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag L2Z20_RS15220 Protein ID WP_000931890.1
Coordinates 3197617..3198006 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z20_RS15225 Protein ID WP_001288210.1
Coordinates 3198013..3198270 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z20_RS15205 (L2Z20_15190) 3192735..3194930 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
L2Z20_RS15210 (L2Z20_15195) 3195118..3195684 - 567 WP_000651536.1 rhombosortase -
L2Z20_RS15215 (L2Z20_15200) 3195762..3196847 - 1086 WP_000049106.1 hypothetical protein -
L2Z20_RS15220 (L2Z20_15205) 3197617..3198006 - 390 WP_000931890.1 membrane protein Toxin
L2Z20_RS15225 (L2Z20_15210) 3198013..3198270 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z20_RS15230 (L2Z20_15215) 3198458..3199630 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z20_RS15235 (L2Z20_15220) 3199681..3201171 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z20_RS15240 (L2Z20_15225) 3201352..3201729 - 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z20_RS15245 (L2Z20_15230) 3201748..3202755 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T233221 WP_000931890.1 NZ_CP091355:c3198006-3197617 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233221 NZ_FO834905:c38034-37564 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCATGGACCGGATATGGTGCGAAAGAGGCTGGTGGACG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCTGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233221 WP_001288210.1 NZ_CP091355:c3198270-3198013 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233221 NZ_FO834905:c38474-38031 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTTGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCTGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGA
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References