Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3106356..3107009 Replicon chromosome
Accession NZ_CP091354
Organism Acinetobacter baumannii strain AB188-VUB

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag L2Z21_RS14895 Protein ID WP_000931890.1
Coordinates 3106620..3107009 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z21_RS14890 Protein ID WP_001288210.1
Coordinates 3106356..3106613 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z21_RS14870 (L2Z21_14865) 3101872..3102879 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
L2Z21_RS14875 (L2Z21_14870) 3102898..3103275 + 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z21_RS14880 (L2Z21_14875) 3103456..3104946 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z21_RS14885 (L2Z21_14880) 3104996..3106168 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z21_RS14890 (L2Z21_14885) 3106356..3106613 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z21_RS14895 (L2Z21_14890) 3106620..3107009 + 390 WP_000931890.1 membrane protein Toxin
L2Z21_RS14900 (L2Z21_14895) 3107779..3108864 + 1086 WP_000049106.1 hypothetical protein -
L2Z21_RS14905 (L2Z21_14900) 3108942..3109508 + 567 WP_000651536.1 rhombosortase -
L2Z21_RS14910 (L2Z21_14905) 3109696..3111891 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T233220 WP_000931890.1 NZ_CP091354:3106620-3107009 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233220 NZ_FO834904:c85848-85561 [Klebsiella pneumoniae]
ATGACATATACCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGAACAAGCTAGATAAGACTATTCAGCAGCAGTTTGC
AAAGAAACTTAAAAAGTGCTGTGAAAACCCACACATTCCTTCAGCAAAACTACGTGGTATAAAGGATTGCTATAAAATAA
AACTGCGAGCATCTGGTTTTCGCCTCGTCTATCAGGTCATAGATAATCAACTTATAATTGCTATTGTGGCTGTAGGCAAA
CGGGAGCGCAGTGACGTTTATACACTGGCGAGTGAACGTATGAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233220 WP_001288210.1 NZ_CP091354:3106356-3106613 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233220 NZ_FO834904:c86096-85845 [Klebsiella pneumoniae]
ATGCCACATATCATTCTGAGTGACACGACTGCCAGCGTCAGTGAATTGAAAAAAAACCCGATGGCCACAGTCAGCGCAGG
TGACGGGTTCCCAGTAGCGATTCTTAACCGGAACCAGCCAGCTTTCTATTGCGTGCCTGCGGAACTCTACGAAAAGATGC
TTGATGCGCTGGATGATCAGGAACTCATTAAACTGGTTGCAGAACGCAGTAATCAACCGCTGTTTGATATGGACCTGGAG
AAGTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References