Detailed information of TA system TA233219

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3047693..3048346
• Replicon: chromosome
• Accession: NZ_CP091353
• Organism: Acinetobacter baumannii strain AB189-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z22_RS14725
• Protein ID: WP_000607077.1
• Coordinates: 3047693..3048082 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z22_RS14730
• Protein ID: WP_001288210.1
• Coordinates: 3048089..3048346 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z22_RS14710 (L2Z22_14705)	3042811..3045006	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
L2Z22_RS14715 (L2Z22_14710)	3045194..3045760	-	567	WP_000651538.1	rhombosortase	-
L2Z22_RS14720 (L2Z22_14715)	3045838..3046923	-	1086	WP_000049106.1	hypothetical protein	-
L2Z22_RS14725 (L2Z22_14720)	3047693..3048082	-	390	WP_000607077.1	membrane protein	Toxin
L2Z22_RS14730 (L2Z22_14725)	3048089..3048346	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z22_RS14735 (L2Z22_14730)	3048534..3049706	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z22_RS14740 (L2Z22_14735)	3049755..3051245	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z22_RS14745 (L2Z22_14740)	3051427..3051804	-	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z22_RS14750 (L2Z22_14745)	3051823..3052830	-	1008	WP_215758501.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233219 WP_000607077.1 NZ_CP091353:c3048082-3047693 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233219 NZ_FO834904:c69987-69571 [Klebsiella pneumoniae]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233219 WP_001288210.1 NZ_CP091353:c3048346-3048089 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233219 NZ_FO834904:c70214-69984 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7