Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1200977..1201656 Replicon chromosome
Accession NZ_CP091353
Organism Acinetobacter baumannii strain AB189-VUB

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Z1VKH9
Locus tag L2Z22_RS05895 Protein ID WP_000838148.1
Coordinates 1200977..1201159 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag L2Z22_RS05900 Protein ID WP_000966688.1
Coordinates 1201252..1201656 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z22_RS05855 (L2Z22_05850) 1196188..1196556 + 369 WP_002019566.1 hypothetical protein -
L2Z22_RS05860 (L2Z22_05855) 1196565..1196972 + 408 WP_000247950.1 hypothetical protein -
L2Z22_RS05865 (L2Z22_05860) 1196944..1197312 + 369 WP_000539750.1 hypothetical protein -
L2Z22_RS05870 (L2Z22_05865) 1197314..1197712 + 399 WP_001251875.1 phage tail terminator-like protein -
L2Z22_RS05875 (L2Z22_05870) 1197781..1198131 + 351 WP_000065011.1 hypothetical protein -
L2Z22_RS05880 (L2Z22_05875) 1198131..1199096 + 966 WP_000002429.1 hypothetical protein -
L2Z22_RS05885 (L2Z22_05880) 1199149..1200066 + 918 WP_000094259.1 phage tail tube protein -
L2Z22_RS05890 (L2Z22_05885) 1200136..1200651 + 516 WP_001185594.1 hypothetical protein -
L2Z22_RS05895 (L2Z22_05890) 1200977..1201159 + 183 WP_000838148.1 type II toxin-antitoxin system HicA family toxin Toxin
L2Z22_RS05900 (L2Z22_05895) 1201252..1201656 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L2Z22_RS05905 (L2Z22_05900) 1201756..1202265 + 510 WP_000734512.1 hypothetical protein -
L2Z22_RS05910 (L2Z22_05905) 1202466..1203398 - 933 WP_001043692.1 IS5-like element ISAba13 family transposase -
L2Z22_RS05915 (L2Z22_05910) 1203703..1205348 + 1646 Protein_1154 phosphoethanolamine--lipid A transferase -
L2Z22_RS05920 (L2Z22_05915) 1205467..1205652 - 186 WP_000878678.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1182322..1203398 21076
- flank IS/Tn - - 1202466..1203398 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6677.82 Da        Isoelectric Point: 10.5523

>T233218 WP_000838148.1 NZ_CP091353:1200977-1201159 [Acinetobacter baumannii]
VKSLDLIKMIEADSWYEVRVSGSHHHVKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T233218 NZ_FO818638:114378-114701 [Xenorhabdus bovienii]
ATGGATTATCTGGAGTTTATCGAAACCACCACATTCAGTAGGGTACGAACCGAACTCATGGAAGATGATGAGTTGCAGGA
ACTCCAAGACCACTTACTGAAACACCATGAAAAGGGCGACACAATTAGTCAAACCGGTGGATGTAAAAAGATTCGCTGGA
GTCGCAAAGGAATGGGGAAGCGTGGTGGGATAAGGGTTATCTACTATGTCAGGACGTTAAGTGGACGATTATATTTGTTG
CTGGTTTATCCCAAAAACGCACAAGCAGACTTAACGCAAGATCAGAAAACACAATTGAAAAATGCTATTCAATATATGAA
ATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT233218 WP_000966688.1 NZ_CP091353:1201252-1201656 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT233218 NZ_FO818638:114756-115052 [Xenorhabdus bovienii]
ATGGATGATAAATTGTTTGACGATTTGCTTAGTAGTGTGAAGGAGATGGTTGCTATCGAAAATGGTGAGTTTCAACCTAA
ACCTGAGCATGTCCACCGCCATGCTATCCCTAGCGTTAAATCTATCCGCAATCATTTTGGTATGAAACAAGTCGAGTTTG
CGGAAATGATAGGAGTCAGCGTTGCGTTAGTACAAAGTTGGGAATCAAAGCGCCGTACCCCATCAGGAACGGCGCTAAAA
ATGTTATTTTTGATAGAGAAAAATCCGAATATTGTAGATACGTTAAAGTCTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z1VKH9

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References