Detailed information of TA system TA233217

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1140767..1141420
• Replicon: chromosome
• Accession: NZ_CP091352
• Organism: Acinetobacter baumannii strain AB193-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z23_RS05485
• Protein ID: WP_000607077.1
• Coordinates: 1141031..1141420 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z23_RS05480
• Protein ID: WP_001288210.1
• Coordinates: 1140767..1141024 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z23_RS05460 (L2Z23_05460)	1136283..1137290	+	1008	WP_077123802.1	DNA-directed RNA polymerase subunit alpha	-
L2Z23_RS05465 (L2Z23_05465)	1137309..1137686	+	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z23_RS05470 (L2Z23_05470)	1137868..1139358	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z23_RS05475 (L2Z23_05475)	1139407..1140579	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z23_RS05480 (L2Z23_05480)	1140767..1141024	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z23_RS05485 (L2Z23_05485)	1141031..1141420	+	390	WP_000607077.1	membrane protein	Toxin
L2Z23_RS05490 (L2Z23_05490)	1142190..1143275	+	1086	WP_000049106.1	hypothetical protein	-
L2Z23_RS05495 (L2Z23_05495)	1143353..1143919	+	567	WP_000651538.1	rhombosortase	-
L2Z23_RS05500 (L2Z23_05500)	1144107..1146302	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233217 WP_000607077.1 NZ_CP091352:1141031-1141420 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233217 NZ_FO818638:61715-62002 [Xenorhabdus bovienii]
GTGATTTATAAGATAAAATTCAGAGAAGATGCGCTAAAAGAATGGAACAAACTAGATAAAGCTATTCTTAAACAGTTTGC
TAAAAAACTGAAAAAATGCTGTGAAAACCCGCGTATTCCATCGGCCAAGCTACGTGGTATGTCGGACTGTTACAAAATTA
AGCTCCGAGCATCCGGTTTTCGTCTAGTTTATCAAATCATTGACGATCAGTTAATTATCGCAGTAATTGCAGTTGGAAAA
CGTGAACGTAGTGATGTTTATAACCTAGCAAGTGAACGGTTACGATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233217 WP_001288210.1 NZ_CP091352:1140767-1141024 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233217 NZ_FO818638:61467-61718 [Xenorhabdus bovienii]
ATGGCAAACTTAATTTTGAGTGATACAAGTGCAAGTATTAGCGAGCTAAAGAAAAATCCAATGGCGACTGTGAATGCTGG
TGCGGGTTATCCCGTAGCTATTCTGAACAGAAACCAACCTGCATTTTATTGTATCCCAGCTGAACTCTATGAAATGATGC
TTGATACAATTGATGATCAAGAACTCGTCAGACTAGTGAAAGAACGTGAAAATCAACCATTAATTGATGTTGATTTGGAC
GAATATCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7