Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3810213..3810892 | Replicon | chromosome |
| Accession | NZ_CP091351 | ||
| Organism | Acinetobacter baumannii strain AB194-VUB | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | S3TWT7 |
| Locus tag | L2Z24_RS18155 | Protein ID | WP_000838146.1 |
| Coordinates | 3810213..3810395 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9L2H6 |
| Locus tag | L2Z24_RS18160 | Protein ID | WP_000966688.1 |
| Coordinates | 3810488..3810892 (+) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2Z24_RS18120 (L2Z24_18090) | 3805233..3805676 | + | 444 | WP_002016455.1 | phage tail terminator-like protein | - |
| L2Z24_RS18125 (L2Z24_18095) | 3805678..3805896 | + | 219 | WP_001277696.1 | hypothetical protein | - |
| L2Z24_RS18130 (L2Z24_18100) | 3806005..3806526 | + | 522 | WP_000749909.1 | SH3 domain-containing protein | - |
| L2Z24_RS18135 (L2Z24_18105) | 3806623..3806976 | + | 354 | WP_000064593.1 | hypothetical protein | - |
| L2Z24_RS18140 (L2Z24_18110) | 3806976..3808331 | + | 1356 | WP_000002415.1 | hypothetical protein | - |
| L2Z24_RS18145 (L2Z24_18115) | 3808384..3809301 | + | 918 | WP_000094253.1 | phage tail tube protein | - |
| L2Z24_RS18150 (L2Z24_18120) | 3809372..3809887 | + | 516 | WP_024616020.1 | hypothetical protein | - |
| L2Z24_RS18155 (L2Z24_18125) | 3810213..3810395 | + | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| L2Z24_RS18160 (L2Z24_18130) | 3810488..3810892 | + | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| L2Z24_RS18165 (L2Z24_18135) | 3810992..3811516 | + | 525 | WP_000721574.1 | DUF4468 domain-containing protein | - |
| L2Z24_RS18170 (L2Z24_18140) | 3811581..3811964 | + | 384 | WP_000725052.1 | hypothetical protein | - |
| L2Z24_RS18175 (L2Z24_18145) | 3812026..3812772 | + | 747 | WP_000599537.1 | hypothetical protein | - |
| L2Z24_RS18180 (L2Z24_18150) | 3812858..3813349 | + | 492 | WP_000755583.1 | DUF4468 domain-containing protein | - |
| L2Z24_RS18185 (L2Z24_18155) | 3813392..3813658 | - | 267 | WP_000774879.1 | hypothetical protein | - |
| L2Z24_RS18190 (L2Z24_18160) | 3813808..3814743 | + | 936 | WP_000254125.1 | ORF6N domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3777547..3835464 | 57917 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T233216 WP_000838146.1 NZ_CP091351:3810213-3810395 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T233216 NZ_FO818638:c4974-4624 [Xenorhabdus bovienii]
TTGTGGACAGTGATTTTTACCCCAAGGTTTGACGCCTGGCTACAGGAGCAAGAAGAAGGGATGCAGGAAAAGGTACTGGC
CGATCTAACCAACCTTGAAACGTATGGGCCGAAATTATCGCGTCCTTACGCCGATACAGTGAAAGGTTCCAGGCACAAAA
ACATGAAAGAACTTCGCGTACAGTATTCAGGCCACCCGGTACGCGCGTTCTTTGCTTTTGACCCTAAACGTCAGGCTATC
GTGTTATGTGCCGGTGACAAAAGTAACAATAAGCGGTTTTACGACACGATGATCCGCATAGCGGATGAAGAATTTACCGC
ACATTTAACCGTGATCGAGGAGCAGAAATGA
TTGTGGACAGTGATTTTTACCCCAAGGTTTGACGCCTGGCTACAGGAGCAAGAAGAAGGGATGCAGGAAAAGGTACTGGC
CGATCTAACCAACCTTGAAACGTATGGGCCGAAATTATCGCGTCCTTACGCCGATACAGTGAAAGGTTCCAGGCACAAAA
ACATGAAAGAACTTCGCGTACAGTATTCAGGCCACCCGGTACGCGCGTTCTTTGCTTTTGACCCTAAACGTCAGGCTATC
GTGTTATGTGCCGGTGACAAAAGTAACAATAAGCGGTTTTACGACACGATGATCCGCATAGCGGATGAAGAATTTACCGC
ACATTTAACCGTGATCGAGGAGCAGAAATGA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT233216 WP_000966688.1 NZ_CP091351:3810488-3810892 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT233216 NZ_FO818638:c4627-4328 [Xenorhabdus bovienii]
ATGAAAACATTACGTGATGCTGTAGCAGCCCGTTCGCCAGAGAGCCAGGCACGGATTAAAGAAATGGCGGATGAAATGAT
TCTGGAAACTGGATTACAGCTGATGCGAGAAGAATTGCAGTTTTCGCAAAAATCCCTGGCTGAATCCATGGGAGTCAGCC
AGCCTGCGATAACTCAAATTGAGCAACGAGGCAATGATGTTAAGTTGGCAACGCTTAAACGTTATATTGAGGCAATGGGC
GGAAAACTGAGTCTGACCGTTGAATTACCAGAAGGAGGGGGACGGATATTTCATATCTGA
ATGAAAACATTACGTGATGCTGTAGCAGCCCGTTCGCCAGAGAGCCAGGCACGGATTAAAGAAATGGCGGATGAAATGAT
TCTGGAAACTGGATTACAGCTGATGCGAGAAGAATTGCAGTTTTCGCAAAAATCCCTGGCTGAATCCATGGGAGTCAGCC
AGCCTGCGATAACTCAAATTGAGCAACGAGGCAATGATGTTAAGTTGGCAACGCTTAAACGTTATATTGAGGCAATGGGC
GGAAAACTGAGTCTGACCGTTGAATTACCAGAAGGAGGGGGACGGATATTTCATATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|