Detailed information of TA system TA233215

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3717802..3718455
• Replicon: chromosome
• Accession: NZ_CP091351
• Organism: Acinetobacter baumannii strain AB194-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z24_RS17590
• Protein ID: WP_000607077.1
• Coordinates: 3718066..3718455 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z24_RS17585
• Protein ID: WP_001288210.1
• Coordinates: 3717802..3718059 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z24_RS17565 (L2Z24_17535)	3713318..3714325	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
L2Z24_RS17570 (L2Z24_17540)	3714344..3714721	+	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z24_RS17575 (L2Z24_17545)	3714903..3716393	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z24_RS17580 (L2Z24_17550)	3716442..3717614	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z24_RS17585 (L2Z24_17555)	3717802..3718059	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z24_RS17590 (L2Z24_17560)	3718066..3718455	+	390	WP_000607077.1	membrane protein	Toxin
L2Z24_RS17595 (L2Z24_17565)	3719225..3720310	+	1086	WP_000049106.1	hypothetical protein	-
L2Z24_RS17600 (L2Z24_17570)	3720388..3720954	+	567	WP_000651538.1	rhombosortase	-
L2Z24_RS17605 (L2Z24_17575)	3721142..3723337	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233215 WP_000607077.1 NZ_CP091351:3718066-3718455 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233215 NZ_FO818637:c4603530-4602955 [Xenorhabdus bovienii]
ATGCAGCACTCTCCCTATCCAGCCGTACTTGATGCATGTGTTTTATACCCGGCAAGATTGCGCGATTTACTTATGCATTT
AGGGCTGGCTGGTTTGTACCAACCCAAATGGTCGGACACTATTCAGGACGAATGGAAGCGAAATTTATTAAAACAGCGCA
GTGATATAAAGCCCGAAGTACTGGAACAAACAACAATATTAATGAATACAGCATTGCCGGATGCTAATGTCACAGGATTT
GAACTGTTAATTGAAGGGTTCAGACTACCTGATGAAGACGATCGCCACGTGCTAGCCACAGCCATACGTGCAAATGCAGA
AGTCATAGTCACTATGAACTTGAAAGACTTTCCGCCCCAAATTTTGGCTGAATTTGATATTGAAGCGCTTCATCCGGACG
AGTTTATTTCAGACCTTTTTGACTTAAACCACGCAGCTGCGCTGGAAGCGGTAAGGCAGCAACGTATAGCATTAAAAAAT
CCACCGATGTCTACGGATGAATTTTTATATATGTTGCTAAAACAGGGATTACCCATGACGGTTAAAGCTATTGATGCTTA
TAGATTTATGGTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233215 WP_001288210.1 NZ_CP091351:3717802-3718059 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233215 NZ_FO818637:c4603998-4603534 [Xenorhabdus bovienii]
ATGAACAACACAACTTTAACCAGCTTGAATCTTCCAGCACAACATGAGATTGAAATCGCAATGCGTGGCCAACGAGAGCT
GGCCACGTTTCTTTCTACTAAATCCGAAACTCAGCAGATTATCATTAACGGTGCTGATAACGTGTCGCACCAAATTGAAC
TGCCTACCTCGGTATTAACCATGCTGATGAATATACTGGGTGAACTGGCGGTAGGCAACGCCGTACAAATTGTACCAGTA
CATGCTGAACTAACGACGCAGGAAGCTGCGAATATAATGAATGTATCGCGTCCTCATATGGTTAAATTATTAGAGGACGG
GAAATTACCTCATCATAAAACAGGGCGGCATCGTCGAGTGTTATTCGCCGAACTGATGGAATACAAAAAGAAACGTGATG
CTGACAGCATAGCTGCTATGCAAGAGCTTGCTGCTCAGGCGCAAGAACTTAACTTGGGCTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7