233214

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2252191..2252779 Replicon chromosome
Accession NZ_CP091350
Organism Acinetobacter baumannii strain AB212-VUB

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag L2Z25_RS10915 Protein ID WP_000438826.1
Coordinates 2252191..2252478 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag L2Z25_RS10920 Protein ID WP_001983304.1
Coordinates 2252465..2252779 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z25_RS10890 (L2Z25_10890) 2247643..2248469 - 827 Protein_2125 AraC family transcriptional regulator -
L2Z25_RS10895 (L2Z25_10895) 2248643..2249349 - 707 Protein_2126 IS1 family transposase -
L2Z25_RS10900 (L2Z25_10900) 2249440..2250282 - 843 WP_002002480.1 carbapenem-hydrolyzing class D beta-lactamase OXA-58 -
L2Z25_RS10905 (L2Z25_10905) 2250517..2251479 + 963 WP_004746678.1 IS30-like element IS18 family transposase -
L2Z25_RS10910 (L2Z25_10910) 2251476..2251961 + 486 WP_220385121.1 LysE family transporter -
L2Z25_RS10915 (L2Z25_10915) 2252191..2252478 + 288 WP_000438826.1 BrnT family toxin Toxin
L2Z25_RS10920 (L2Z25_10920) 2252465..2252779 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
L2Z25_RS10925 (L2Z25_10925) 2252907..2255318 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
L2Z25_RS10930 (L2Z25_10930) 2255623..2256084 + 462 WP_000761346.1 DIP1984 family protein -
L2Z25_RS10935 (L2Z25_10935) 2256407..2256580 - 174 WP_001282484.1 hypothetical protein -
L2Z25_RS10940 (L2Z25_10940) 2256580..2256951 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T233214 WP_000438826.1 NZ_CP091350:2252191-2252478 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T233214 NZ_FO818637:c4143239-4142835 [Xenorhabdus bovienii]
ATGATTAAATATTTATTAGATACAAATATCGTAATATTTACGATTAAACGTAAACCAGAATCTCTATTACCTAAATTTAA
TCAACACACTAATCAACTTGCTATTTCTGCAATAACGCTCGCAGAGTTAATTTTCGGAGCTGAAAAAAGCATGAATCCCA
CTAAAAATCTAGCCACTGTTAATGACTTTGTATCACGTTTGACCGTTTTACCTTATGACGAACAAGCAGCATTTCACTAC
GGTGATATAAGGGCTATTCTTGAAAAAAAAGGAAAACGTATTGGTGATAACGACTTACACATAGCGGCTCATGCCAGAAG
TAAAGGACTTATTGTAGTAACAAATAATACAAGAGAGTTTGAAAGAGTTGATGGATTAAGAATAGAAGATTGGACTAAGC
CCTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT233214 WP_001983304.1 NZ_CP091350:2252465-2252779 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT233214 NZ_FO818637:c4143471-4143232 [Xenorhabdus bovienii]
ATCCAGCAAGGTAAAGTCTTTATGAGTAATCGAACTCAAAATGTTCGCTTACCGGCAGATACACGTTTCCCTGATAACGT
TAAAGAGGTTATTGTTCGAGTTAGCGGAAAGGAACGTATAATCTCTCCCGTCCAAAACGCATGGGATAGCTTTTTCTTAT
CAGATCAGTCTGTAACAGATGATTTTTTGCCAAACAGAGCTGATCAGATAACAAGCGAAAGAGAATCCTTCGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References