Detailed information of TA system TA233209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3428074..3428725
• Replicon: chromosome
• Accession: NZ_CP091347
• Organism: Acinetobacter baumannii strain AB216-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z29_RS16390
• Protein ID: WP_000838146.1
• Coordinates: 3428543..3428725 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: L2Z29_RS16385
• Protein ID: WP_000966689.1
• Coordinates: 3428074..3428478 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z29_RS16370 (L2Z29_16370)	3423107..3423448	-	342	WP_001281459.1	phage tail protein	-
L2Z29_RS16375 (L2Z29_16375)	3423566..3427531	-	3966	WP_000191304.1	tape measure protein	-
L2Z29_RS16380 (L2Z29_16380)	3427592..3427993	-	402	WP_000720591.1	hypothetical protein	-
L2Z29_RS16385 (L2Z29_16385)	3428074..3428478	-	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z29_RS16390 (L2Z29_16390)	3428543..3428725	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z29_RS16395 (L2Z29_16395)	3429057..3429590	-	534	WP_001185622.1	hypothetical protein	-
L2Z29_RS16400 (L2Z29_16400)	3429635..3430564	-	930	WP_000094299.1	phage tail tube protein	-
L2Z29_RS16405 (L2Z29_16405)	3430672..3430884	-	213	WP_000121166.1	hypothetical protein	-
L2Z29_RS16410 (L2Z29_16410)	3430886..3431284	-	399	WP_001132270.1	hypothetical protein	-
L2Z29_RS16415 (L2Z29_16415)	3431286..3431654	-	369	WP_000539752.1	hypothetical protein	-
L2Z29_RS16420 (L2Z29_16420)	3431626..3432030	-	405	WP_000248323.1	hypothetical protein	-
L2Z29_RS16425 (L2Z29_16425)	3432039..3432407	-	369	WP_000524231.1	hypothetical protein	-
L2Z29_RS16430 (L2Z29_16430)	3432409..3432798	-	390	WP_000008492.1	hypothetical protein	-
L2Z29_RS16435 (L2Z29_16435)	3432803..3433468	-	666	WP_000767881.1	Ish1 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3403417..3469653	66236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233209 WP_000838146.1 NZ_CP091347:c3428725-3428543 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233209 NZ_FO818637:c787979-787698 [Xenorhabdus bovienii]
ATGCGGACGACTGATTATACAAGCCAGTTTAAGCGAGATTACAAGAGAGAAAAGAAAGGTCGTCATCGTGAAACTCTGGA
TGACGCACTTATGACGGTGACTGAATTATTGGCCTCTGATAGCTTGCTAGAACCGAAATATTGTGATCATGCCCTTTCTG
GTGATTGGAAGGATTTTCGAGACTGCCACATTAAACCTGACTTGATATTGATTTATCAGAAGCCAGACGCTGACATATTA
CGCCTTGTCCGCCTTGGTTCTCACTCAGAGCTTGGCTTATAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT233209 WP_000966689.1 NZ_CP091347:c3428478-3428074 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233209 NZ_FO818637:c788229-787966 [Xenorhabdus bovienii]
ATGGCTACAAACCAGCTAATACAAACCCGTATTGACGGTGAGATTAAAGCAGAAGCGGCTGCTGTTTTGGCTGCGATGGG
ACTGACTGTATCAGATGCCGTCCGCATGATGTTAACGCGAGTGGCAAGAGATAAGATATTGCCGTTTGAGCCTCTGATAC
CGAATGAGACAACAATAGCCGCAATGAAAGAAGCTCGCAAAGGTGGCGGTAAATCATTTTCCTCAGTTAAAGATTTAATG
GCTGATCTCAATGCGGACGACTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8