Detailed information of TA system TA233204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2640606..2641257
• Replicon: chromosome
• Accession: NZ_CP091345
• Organism: Acinetobacter baumannii strain AB219-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z31_RS12560
• Protein ID: WP_000838146.1
• Coordinates: 2641075..2641257 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: L2Z31_RS12555
• Protein ID: WP_000966689.1
• Coordinates: 2640606..2641010 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z31_RS12540 (L2Z31_12540)	2635639..2635980	-	342	WP_001281459.1	phage tail protein	-
L2Z31_RS12545 (L2Z31_12545)	2636098..2640063	-	3966	WP_000191304.1	tape measure protein	-
L2Z31_RS12550 (L2Z31_12550)	2640124..2640525	-	402	WP_000720591.1	hypothetical protein	-
L2Z31_RS12555 (L2Z31_12555)	2640606..2641010	-	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z31_RS12560 (L2Z31_12560)	2641075..2641257	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z31_RS12565 (L2Z31_12565)	2641589..2642122	-	534	WP_001185622.1	hypothetical protein	-
L2Z31_RS12570 (L2Z31_12570)	2642167..2643096	-	930	WP_000094299.1	phage tail tube protein	-
L2Z31_RS12575 (L2Z31_12575)	2643204..2643416	-	213	WP_000121166.1	hypothetical protein	-
L2Z31_RS12580 (L2Z31_12580)	2643418..2643816	-	399	WP_001132270.1	hypothetical protein	-
L2Z31_RS12585 (L2Z31_12585)	2643818..2644186	-	369	WP_000539752.1	hypothetical protein	-
L2Z31_RS12590 (L2Z31_12590)	2644158..2644562	-	405	WP_000248323.1	hypothetical protein	-
L2Z31_RS12595 (L2Z31_12595)	2644571..2644939	-	369	WP_000524231.1	hypothetical protein	-
L2Z31_RS12600 (L2Z31_12600)	2644941..2645330	-	390	WP_000008492.1	hypothetical protein	-
L2Z31_RS12605 (L2Z31_12605)	2645335..2646000	-	666	WP_000767881.1	Ish1 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2615949..2671651	55702

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233204 WP_000838146.1 NZ_CP091345:c2641257-2641075 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233204 NZ_FO704551:c1371963-1371778 [Xenorhabdus poinarii G6]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAGAATGGATGGGTACTTGATAGAATAAAGGGAAGTCATCATCAATT
TACCCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACGCTAAATCAAATTC
TTAAGAATGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT233204 WP_000966689.1 NZ_CP091345:c2641010-2640606 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233204 NZ_FO704551:c1371732-1371319 [Xenorhabdus poinarii G6]
ATGTTATACCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCCAGTGGCTGGTTCCCTGATATTGATGGCTGTATCTT
TGCGGGGGACAGTATTGAAGAGGCTCACGCCGATGCCATATCCGCTATCAATGCACACTTTGAATTATTAAGTGAGAAAG
GATTTGATATTCCCTCGCCAAAATCACAACAAACTCATTTAATGAATTCAATTAATGATTATAAAAATGGGGTCTGGTTT
TTAGTCGATATCGATATCGATAAATATGACGGACGAGCAGAACGTATTAATATTACATTGCCACATCGCTTGTTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGAAGCGGATTTATTGCCACTGCTACCCGTAAAGAGCTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8