Detailed information of TA system TA233203

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3123199..3123852
• Replicon: chromosome
• Accession: NZ_CP091344
• Organism: Acinetobacter baumannii strain AB220-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z32_RS14930
• Protein ID: WP_000607077.1
• Coordinates: 3123463..3123852 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z32_RS14925
• Protein ID: WP_001288210.1
• Coordinates: 3123199..3123456 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z32_RS14905 (L2Z32_14900)	3118715..3119722	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
L2Z32_RS14910 (L2Z32_14905)	3119741..3120118	+	378	WP_215742073.1	50S ribosomal protein L17	-
L2Z32_RS14915 (L2Z32_14910)	3120300..3121790	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z32_RS14920 (L2Z32_14915)	3121839..3123011	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z32_RS14925 (L2Z32_14920)	3123199..3123456	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z32_RS14930 (L2Z32_14925)	3123463..3123852	+	390	WP_000607077.1	membrane protein	Toxin
L2Z32_RS14935 (L2Z32_14930)	3124622..3125707	+	1086	WP_000049106.1	hypothetical protein	-
L2Z32_RS14940 (L2Z32_14935)	3125785..3126351	+	567	WP_000651538.1	rhombosortase	-
L2Z32_RS14945 (L2Z32_14940)	3126539..3128734	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233203 WP_000607077.1 NZ_CP091344:3123463-3123852 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233203 NZ_FO704551:c987529-987353 [Xenorhabdus poinarii G6]
GTGAAACAAAGCGAGTTTTTAAAGTGGCTAAAAGCCCACGGGGTAGAAACTGAAAATGGTAAAAAACATTTGAAACTCTA
CTACAAAGGCAAAATAAGCCATCTTCCCAGACATCCCAGTCAGGAGTTAACAACGGGCTTGGTTGAGGGAATAAAGAAAC
AGTTAGGTTTGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233203 WP_001288210.1 NZ_CP091344:3123199-3123456 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233203 NZ_FO704551:c987291-986875 [Xenorhabdus poinarii G6]
ATGTACTATCCTGCGGAATTTGTTAAAGAAGATAACGGATATACAGTCACATTTAGGGATATCCCTGAAGCCATCACTTG
TGGTACAGATATGCCTGAAGCAATGGAAATGGCCGAGGATGTTTTACTTTCCTGTGTCGAAATATACTTTGATATGGATA
AAAACTTTCCTCTGCCTAATTCTGAGATTCAAGAGGATGAGCAGTGGGTATACTTACCTGATAGCGTGTACGCTAAAATC
TTACTTAATAATGAGTTGCTAAAAGCTAACATTAATAAGGCTGAGTTATCACGTTTAACCGGTATCCGCCCCCCTGAAAT
CCAAAGAATACTCGCACCGCGCCATGCAACTAAAATTGATACGATTAGCCGGGCAGTTGCCGCTATAGGTAAAAAGCTAT
CACTTTCAGTTATCTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7