Detailed information of TA system TA233201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1915461..1916140
• Replicon: chromosome
• Accession: NZ_CP091343
• Organism: Acinetobacter baumannii strain AB222-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7Z1VKH9
• Locus tag: L2Z33_RS09285
• Protein ID: WP_000838148.1
• Coordinates: 1915958..1916140 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: L2Z33_RS09280
• Protein ID: WP_000966688.1
• Coordinates: 1915461..1915865 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z33_RS09265 (L2Z33_09265)	1911768..1913414	-	1647	WP_003383679.1	phosphoethanolamine--lipid A transferase	-
L2Z33_RS09270 (L2Z33_09270)	1913719..1914651	+	933	WP_001043692.1	IS5-like element ISAba13 family transposase	-
L2Z33_RS09275 (L2Z33_09275)	1914852..1915361	-	510	WP_000734512.1	hypothetical protein	-
L2Z33_RS09280 (L2Z33_09280)	1915461..1915865	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z33_RS09285 (L2Z33_09285)	1915958..1916140	-	183	WP_000838148.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z33_RS09290 (L2Z33_09290)	1916466..1916981	-	516	WP_001185594.1	hypothetical protein	-
L2Z33_RS09295 (L2Z33_09295)	1917051..1917968	-	918	WP_000094259.1	phage tail tube protein	-
L2Z33_RS09300 (L2Z33_09300)	1918021..1918986	-	966	WP_000002429.1	hypothetical protein	-
L2Z33_RS09305 (L2Z33_09305)	1918986..1919336	-	351	WP_000065011.1	hypothetical protein	-
L2Z33_RS09310 (L2Z33_09310)	1919405..1919803	-	399	WP_001251875.1	phage tail terminator-like protein	-
L2Z33_RS09315 (L2Z33_09315)	1919805..1920173	-	369	WP_000539750.1	hypothetical protein	-
L2Z33_RS09320 (L2Z33_09320)	1920145..1920552	-	408	WP_000247950.1	hypothetical protein	-
L2Z33_RS09325 (L2Z33_09325)	1920561..1920929	-	369	WP_002019566.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1905535..1956197	50662
	-	flank	IS/Tn	-	-	1913719..1914651	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6677.82 Da
• Isoelectric Point: 10.5523

>T233201 WP_000838148.1 NZ_CP091343:c1916140-1915958 [Acinetobacter baumannii]
VKSLDLIKMIEADSWYEVRVSGSHHHVKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233201 NZ_FO704551:c338522-338241 [Xenorhabdus poinarii G6]
ATGATCAAAAGTTTTAAACATAAAGGCTTAGAAAAATTCTTTAAAACAGGCTCTACAGCAGGCATTCAAACAAGCCACGC
TGTAAAACTGAATATTCAACTAACCGCATTAAACACCGCCAAAAAACCCGATGACATGAATGCGCCTGGCTGGAAATTAC
ATCCATTAAAGGGCGCTGATTTAAAAGGCCATTGGGCTATTTCTGTCAACGGAAACTGGCGGCTGACATTTCGCTTTGAA
GGCGAAGATGCCATTTTGGTTAATTATCAAGATTATCACTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT233201 WP_000966688.1 NZ_CP091343:c1915865-1915461 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233201 NZ_FO704551:c338229-337948 [Xenorhabdus poinarii G6]
ATGAACAGAATGTATAATCCCGCGCATCCCGGAATTGTCTTGCGTGAATATTTAGGCGACATTTCTGTTACAGAAGCAGC
AAAAGCACTTGGCGTAACTCGTGCGGCGCTATCCCGTATTTTAAATGGCAACACAGGCATATCCGCAGATATGGCACTTC
GTTTAGAAGTGGCATTAGGAACCAGTGCCGAAATGTGGACGAACATGCAGTCCCAGTATGAGTTATGGCAGGCTTCCCAA
CAACAGCGCCCTGAAATCAGGCCGATATTCGCTCACCTGTAA

Structures

Toxin

• AlphaFold DB: A0A7Z1VKH9

Antitoxin

• AlphaFold DB: N9L2H6