Detailed information of TA system TA233200

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1153681..1154334
• Replicon: chromosome
• Accession: NZ_CP091342
• Organism: Acinetobacter baumannii strain AB224-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z34_RS05550
• Protein ID: WP_000607077.1
• Coordinates: 1153681..1154070 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z34_RS05555
• Protein ID: WP_001288210.1
• Coordinates: 1154077..1154334 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z34_RS05535 (L2Z34_05535)	1148799..1150994	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
L2Z34_RS05540 (L2Z34_05540)	1151182..1151748	-	567	WP_000651538.1	rhombosortase	-
L2Z34_RS05545 (L2Z34_05545)	1151826..1152911	-	1086	WP_000049106.1	hypothetical protein	-
L2Z34_RS05550 (L2Z34_05550)	1153681..1154070	-	390	WP_000607077.1	membrane protein	Toxin
L2Z34_RS05555 (L2Z34_05555)	1154077..1154334	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z34_RS05560 (L2Z34_05560)	1154522..1155694	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z34_RS05565 (L2Z34_05565)	1155743..1157233	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z34_RS05570 (L2Z34_05570)	1157415..1157792	-	378	WP_064894046.1	50S ribosomal protein L17	-
L2Z34_RS05575 (L2Z34_05575)	1157811..1158818	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233200 WP_000607077.1 NZ_CP091342:c1154070-1153681 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233200 NZ_FO704550:c4113111-4112611 [Xenorhabdus doucetiae]
ATGATAATTTCGGAACCAAAACTTCTGGCTGACTATCATCATCTGGAATCTTTTGATTCAGGAGTTGTGACGTTCGATCA
ATGGCTGAAAAATCGCGCACTAAAAAATAACTTAACAGGCGCATCAAAAACCTATGTGGTGTGTGATGAAAATCGGGTGA
TGGCTTACTATTCTCTGGCAGCAAGTGCGATTGTTATGGGTTCTGCTCCCGGCCATTTTAAGCGGAATATGCCTAACCCG
ATACCAGTGGTTGTGTTGGGGCGTTTGGCGGTTGATCGGCGATTGCAGCGAAAGGGAATAGGACGGGCATTGGTGAAAGA
TGCGGCTTTAAGGGTAATACAAGCCGCTGATCTTATTGGTGTTCGCGGCATGATAATTCATGCACTCTCAGATGAAGCAA
AATCATTTTATGAAGCAACCGGATTTGAACCATCGCCTTTAGATCCCATGTTATTGATGGCGACATTGATGGATTTAAAA
AGCGCCTGTACAGATAGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233200 WP_001288210.1 NZ_CP091342:c1154334-1154077 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233200 NZ_FO704550:c4113386-4113108 [Xenorhabdus doucetiae]
ATGCAAACAACAAAACGCGACACATTGAATATTCGTATCAAGCCCGAAATCCGCAACCTGATAGACAGGGCAGCAGCCAT
TCAGGGGAAAAATCGGACGGATTTTATGTTGGAAGCCGCCCGTCGTATGGCAGAAGAGACGTTAATTGAACAAGCGATTA
TTACGGCCAGTCCAGAAGCCTATGCCGAATTTTTGGCACGTTTGGACATGCCCCCACAGCCCAATAAGCCGTTACAAGCA
ACCCTGCAAATGGAAACGCCTTGGGGCAAAGAGCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7