Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 399307..399986 | Replicon | chromosome |
| Accession | NZ_CP091342 | ||
| Organism | Acinetobacter baumannii strain AB224-VUB | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | S3TWT7 |
| Locus tag | L2Z34_RS02000 | Protein ID | WP_000838146.1 |
| Coordinates | 399804..399986 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9L2H6 |
| Locus tag | L2Z34_RS01995 | Protein ID | WP_000966688.1 |
| Coordinates | 399307..399711 (-) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2Z34_RS01960 (L2Z34_01960) | 394600..395115 | - | 516 | WP_001056868.1 | Rha family transcriptional regulator | - |
| L2Z34_RS01965 (L2Z34_01965) | 395456..396391 | - | 936 | WP_000254125.1 | ORF6N domain-containing protein | - |
| L2Z34_RS01970 (L2Z34_01970) | 396541..396807 | + | 267 | WP_000774879.1 | hypothetical protein | - |
| L2Z34_RS01975 (L2Z34_01975) | 396850..397341 | - | 492 | WP_000755583.1 | DUF4468 domain-containing protein | - |
| L2Z34_RS01980 (L2Z34_01980) | 397427..398173 | - | 747 | WP_000599537.1 | hypothetical protein | - |
| L2Z34_RS01985 (L2Z34_01985) | 398235..398618 | - | 384 | WP_000725052.1 | hypothetical protein | - |
| L2Z34_RS01990 (L2Z34_01990) | 398683..399207 | - | 525 | WP_000721574.1 | DUF4468 domain-containing protein | - |
| L2Z34_RS01995 (L2Z34_01995) | 399307..399711 | - | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| L2Z34_RS02000 (L2Z34_02000) | 399804..399986 | - | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| L2Z34_RS02005 (L2Z34_02005) | 400312..400827 | - | 516 | WP_001185592.1 | hypothetical protein | - |
| L2Z34_RS02010 (L2Z34_02010) | 400897..401814 | - | 918 | WP_000094273.1 | phage tail tube protein | - |
| L2Z34_RS02015 (L2Z34_02015) | 401867..403022 | - | 1156 | Protein_394 | phage tail protein | - |
| L2Z34_RS02020 (L2Z34_02020) | 403022..403375 | - | 354 | WP_032051762.1 | hypothetical protein | - |
| L2Z34_RS02025 (L2Z34_02025) | 403471..403689 | - | 219 | WP_002002228.1 | hypothetical protein | - |
| L2Z34_RS02030 (L2Z34_02030) | 403691..404089 | - | 399 | WP_002062850.1 | phage tail terminator-like protein | - |
| L2Z34_RS02035 (L2Z34_02035) | 404091..404459 | - | 369 | WP_001993865.1 | hypothetical protein | - |
| L2Z34_RS02040 (L2Z34_02040) | 404431..404835 | - | 405 | WP_000247952.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 380297..429884 | 49587 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T233199 WP_000838146.1 NZ_CP091342:c399986-399804 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T233199 NZ_FO704550:3726646-3726834 [Xenorhabdus doucetiae]
ATGAGCAGTACAGAGTTAATAAAGCGCCTAATGGCTAATGGATGGATAAAGGATAGACAAGACGGTAGTCATGTCACATT
AACCAAGCCGGGAGTCACGAAGATAATCACCGTACCGCATCCTAGAAAGGATGCTTCAAAAGGGGTTATCCGGCAGGCAC
AAAATATTTCAGGATTGAAATTGCTGTAA
ATGAGCAGTACAGAGTTAATAAAGCGCCTAATGGCTAATGGATGGATAAAGGATAGACAAGACGGTAGTCATGTCACATT
AACCAAGCCGGGAGTCACGAAGATAATCACCGTACCGCATCCTAGAAAGGATGCTTCAAAAGGGGTTATCCGGCAGGCAC
AAAATATTTCAGGATTGAAATTGCTGTAA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT233199 WP_000966688.1 NZ_CP091342:c399711-399307 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT233199 NZ_FO704550:3726897-3727304 [Xenorhabdus doucetiae]
ATGATTTATCCGCTCTTTATCTTTAAAGCAGAAGATGGGTTTGACGGTTACTTTCCAGATGTTGAAGGCTGTTTTTTCGC
CGGCAATACCTTGGAAGAAGCTATCCGTGATGCTGAAAAAGCTTTCGGCCAGCACATGGAAGTTTTAACTGAGCAAGGCG
GGTACGTTCCCGCACCTAAAGACCCATCAGGTTACATCAATGATTCTCGCTTATCTGAGGATGGCGGAGTTATTGCACTG
ATTGAGTTAGATCCTGCGAAATATGAGTCAAAGGCGGTCAAATTCAATTTAACCATGCCTGGCAATCTATTAACCGCTAT
AGATCGCTACATTGAAGAAAACGGTTACTATAAAAATCGTTCTGCTTTCCTCGCTGAATTAGCCAGAAAAGAAATTGCTC
ACCCTTAA
ATGATTTATCCGCTCTTTATCTTTAAAGCAGAAGATGGGTTTGACGGTTACTTTCCAGATGTTGAAGGCTGTTTTTTCGC
CGGCAATACCTTGGAAGAAGCTATCCGTGATGCTGAAAAAGCTTTCGGCCAGCACATGGAAGTTTTAACTGAGCAAGGCG
GGTACGTTCCCGCACCTAAAGACCCATCAGGTTACATCAATGATTCTCGCTTATCTGAGGATGGCGGAGTTATTGCACTG
ATTGAGTTAGATCCTGCGAAATATGAGTCAAAGGCGGTCAAATTCAATTTAACCATGCCTGGCAATCTATTAACCGCTAT
AGATCGCTACATTGAAGAAAACGGTTACTATAAAAATCGTTCTGCTTTCCTCGCTGAATTAGCCAGAAAAGAAATTGCTC
ACCCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|