Detailed information of TA system TA233198

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 288199..288852
• Replicon: chromosome
• Accession: NZ_CP091341
• Organism: Acinetobacter baumannii strain AB226-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z35_RS01540
• Protein ID: WP_000607077.1
• Coordinates: 288199..288588 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z35_RS01545
• Protein ID: WP_001288210.1
• Coordinates: 288595..288852 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z35_RS01525 (L2Z35_01525)	283317..285512	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
L2Z35_RS01530 (L2Z35_01530)	285700..286266	-	567	WP_000651538.1	rhombosortase	-
L2Z35_RS01535 (L2Z35_01535)	286344..287429	-	1086	WP_000049106.1	hypothetical protein	-
L2Z35_RS01540 (L2Z35_01540)	288199..288588	-	390	WP_000607077.1	membrane protein	Toxin
L2Z35_RS01545 (L2Z35_01545)	288595..288852	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z35_RS01550 (L2Z35_01550)	289040..290212	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z35_RS01555 (L2Z35_01555)	290261..291751	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z35_RS01560 (L2Z35_01560)	291933..292310	-	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z35_RS01565 (L2Z35_01565)	292329..293336	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233198 WP_000607077.1 NZ_CP091341:c288588-288199 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233198 NZ_FO704550:c3628264-3628088 [Xenorhabdus doucetiae]
GTGAAGCAGAGTGAGTTCAGGCGGTGGCTTGAGTCTCAAGGGGTGAAAATCAAGAATGGAAAGAATCACTTGATACTCTT
ATATGGAGACGCGAGAAGTGCAATGCCAAGACATCCGAGCAAAGAGATTAACGAAAAATTAAGGTTAGGTATCCTTAAAC
AGTTAAAACTCAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233198 WP_001288210.1 NZ_CP091341:c288852-288595 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233198 NZ_FO704550:c3628032-3627619 [Xenorhabdus doucetiae]
ATGCGATATCCAGTCAATATCGAAGAAGACGGAACGAACTTGTTTGTCTCGTTCCCTGATATACCCGAAGCACTAACGTG
CGGCGATGATTTGGCCGACGCAAAAGCGATGGCCTATGATGCGTTACTCACTGCTTTTTCCATGTACTTTGATGATGAGG
ATAAAGAAATTCCGTTACCAGGTCATACGGTAACAGAACACTATATTGATATTCCGGCCAGCGTTGCAGCTAAAATACTT
TTGCTTAATGCAATGGTAAGGTCAGGCGTCAGCCGTTCGGAACTGGGGCGCCGTGTTGGCATTCAAAAGCAGAACGTCAA
GCAATTGCTGGATGTGTATCACGCGACAAAGATTGACACAATAGAAAAGGCGCTATCAAGTTTAGGTTATGAATTAATCC
TAACGGCTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7