Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 432196..432849 Replicon chromosome
Accession NZ_CP091340
Organism Acinetobacter baumannii strain AB227-VUB

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag L2Z36_RS02115 Protein ID WP_000931890.1
Coordinates 432460..432849 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z36_RS02110 Protein ID WP_001288210.1
Coordinates 432196..432453 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z36_RS02090 (L2Z36_02090) 427712..428719 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
L2Z36_RS02095 (L2Z36_02095) 428738..429115 + 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z36_RS02100 (L2Z36_02100) 429296..430786 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z36_RS02105 (L2Z36_02105) 430836..432008 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z36_RS02110 (L2Z36_02110) 432196..432453 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z36_RS02115 (L2Z36_02115) 432460..432849 + 390 WP_000931890.1 membrane protein Toxin
L2Z36_RS02120 (L2Z36_02120) 433619..434704 + 1086 WP_000049106.1 hypothetical protein -
L2Z36_RS02125 (L2Z36_02125) 434782..435348 + 567 WP_000651536.1 rhombosortase -
L2Z36_RS02130 (L2Z36_02130) 435536..437731 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T233197 WP_000931890.1 NZ_CP091340:432460-432849 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233197 NZ_FO704550:c3337699-3337328 [Xenorhabdus doucetiae]
ATGCGCGTTATCACAGCAAAAACCATCACTGAAGCGATGCAAAAACACGCCCAATGGAAAGTTGGGCTAAAACTCTGGTT
GGATGTTTTTGATAAGGTATCTTTACGATTTGAATCTTATGCCCAAATCCGTGAATTATGGCTTAATACATCTACATGGA
ATGTTGATCGTGTACCCTACGAATTATTAGAAGCAGAAAGCAAGAAAGGGCCTTTAGATATTTATGTATTTGATATACAT
AAAAATAAATGTCGCATTATCACATGGCTTAATCCCAAATCAGGTACTTTTTACATTAAAGATGTTTGCCCCCATAGTGA
GTATGATAAATGGTGGCGTAAGCAGACAAAGTCAAAACGATCAAAAAGGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233197 WP_001288210.1 NZ_CP091340:432196-432453 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233197 NZ_FO704550:c3337324-3336851 [Xenorhabdus doucetiae]
ATGAGAAAAACATCACTCGTTACTTATGAAGGGATTGATGGACTCATCGAAATTTTACCACAAATGATGCAGTCAATATC
CGAGCAACTCGGCCCCTTGGCACTTTTGTTCTCTGCATGTATTGAACCTGTAGAAAATGATGAAGATCTGAATGCCCGAA
TGGCACTTATTGACGAGTTATATTCATATGCTGAAAATACCGAACATGCTGCGGCAAAGTTCGCTGATCTTATCACCGAT
CGTGTCTATGAGTACGAAGCTAAAAATCGCCAAGTCCCCAATGTTATCCCACGTGAAGCATTGAGCTACTTTATGCGGGA
AAAAGGCGTAAGACAGATTGATCTGCGTGATATTGCCAGCCAAAGTGTTATATCAGAGATACTGCATGGAAAACGTTCAA
TGAATATTGGTCAGGTAAAAGGCTTTGCCCAATTTTTTAACGTTCCTGTCGAAACCTTTATGGGTTCAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References