Detailed information of TA system TA233195

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2195309..2195962
• Replicon: chromosome
• Accession: NZ_CP091338
• Organism: Acinetobacter baumannii strain AB231-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A9E9PBS3
• Locus tag: L2Z39_RS10430
• Protein ID: WP_002096593.1
• Coordinates: 2195309..2195698 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z39_RS10435
• Protein ID: WP_001288210.1
• Coordinates: 2195705..2195962 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z39_RS10415 (L2Z39_10415)	2190496..2192622	-	2127	Protein_2042	TRAP transporter large permease subunit	-
L2Z39_RS10420 (L2Z39_10420)	2192810..2193376	-	567	WP_000651536.1	rhombosortase	-
L2Z39_RS10425 (L2Z39_10425)	2193454..2194539	-	1086	WP_000049106.1	hypothetical protein	-
L2Z39_RS10430 (L2Z39_10430)	2195309..2195698	-	390	WP_002096593.1	hypothetical protein	Toxin
L2Z39_RS10435 (L2Z39_10435)	2195705..2195962	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z39_RS10440 (L2Z39_10440)	2196150..2197322	+	1173	WP_001190548.1	acyl-CoA dehydrogenase family protein	-
L2Z39_RS10445 (L2Z39_10445)	2197371..2198861	-	1491	WP_004745487.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z39_RS10450 (L2Z39_10450)	2199043..2199420	-	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z39_RS10455 (L2Z39_10455)	2199439..2200446	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15677.99 Da
• Isoelectric Point: 10.3890

>T233195 WP_002096593.1 NZ_CP091338:c2195698-2195309 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233195 NZ_FO704550:936648-936932 [Xenorhabdus doucetiae]
ATGAAATCAGAACCGAAAAAATTTGATGTTGTGGAGTTTTTAGAAACAGAAGACGATATTCAGGCATACTTAAATGCTGC
TATCGAAGAGAACGATACAAAATATTTATTTAAAGCGTTAGGTAATATTGCCAGAATAAAAAATATCAGCCAACTATCTA
AAGAGTCAGGAATAAGTCGAGAGGGGATATATAAGGCGTTATCCGACGAAGGCAACCCATCATTTAATACGGTATACAAA
ATATCAAAAGCACTGGGTTTGAAACTGCATTTCACTGGAGCTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233195 WP_001288210.1 NZ_CP091338:c2195962-2195705 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233195 NZ_FO704550:936350-936646 [Xenorhabdus doucetiae]
ATGATAACCATTGAGAGGACTCAGGATTTTGAAAAATGGTTAAAATCCTTAAAAGACAGGATAGCAAAAACCAAGATCTT
AATCAGGGTTGAAAGAATGGAAGAGGGAAATTTTGGCGATGTTGAACCTGTGGGGAGCGGGGTTTCGGAACTCAAAATAC
ATGACGGGCAAGGCTATCGTGTCTACTTTGCTAACAAAAATAATGAAATAATATTATTACTCTGTGGCGGAGATAAAAGC
AGCCAGCAGGAAGATATAAAGAAAGCCAAACAACTTGCAAAAGAATGGGGATTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7