Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 36320..36973 Replicon chromosome
Accession NZ_CP091337
Organism Acinetobacter baumannii strain AB232-VUB

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag L2Z40_RS00185 Protein ID WP_000931890.1
Coordinates 36320..36709 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z40_RS00190 Protein ID WP_001288210.1
Coordinates 36716..36973 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z40_RS00170 (L2Z40_00170) 31438..33633 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
L2Z40_RS00175 (L2Z40_00175) 33821..34387 - 567 WP_000651536.1 rhombosortase -
L2Z40_RS00180 (L2Z40_00180) 34465..35550 - 1086 WP_000049106.1 hypothetical protein -
L2Z40_RS00185 (L2Z40_00185) 36320..36709 - 390 WP_000931890.1 membrane protein Toxin
L2Z40_RS00190 (L2Z40_00190) 36716..36973 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z40_RS00195 (L2Z40_00195) 37161..38333 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z40_RS00200 (L2Z40_00200) 38383..39873 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z40_RS00205 (L2Z40_00205) 40054..40431 - 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z40_RS00210 (L2Z40_00210) 40450..41457 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T233194 WP_000931890.1 NZ_CP091337:c36709-36320 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233194 NZ_FO704550:936350-936646 [Xenorhabdus doucetiae]
ATGATAACCATTGAGAGGACTCAGGATTTTGAAAAATGGTTAAAATCCTTAAAAGACAGGATAGCAAAAACCAAGATCTT
AATCAGGGTTGAAAGAATGGAAGAGGGAAATTTTGGCGATGTTGAACCTGTGGGGAGCGGGGTTTCGGAACTCAAAATAC
ATGACGGGCAAGGCTATCGTGTCTACTTTGCTAACAAAAATAATGAAATAATATTATTACTCTGTGGCGGAGATAAAAGC
AGCCAGCAGGAAGATATAAAGAAAGCCAAACAACTTGCAAAAGAATGGGGATTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233194 WP_001288210.1 NZ_CP091337:c36973-36716 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233194 NZ_FO704550:936648-936932 [Xenorhabdus doucetiae]
ATGAAATCAGAACCGAAAAAATTTGATGTTGTGGAGTTTTTAGAAACAGAAGACGATATTCAGGCATACTTAAATGCTGC
TATCGAAGAGAACGATACAAAATATTTATTTAAAGCGTTAGGTAATATTGCCAGAATAAAAAATATCAGCCAACTATCTA
AAGAGTCAGGAATAAGTCGAGAGGGGATATATAAGGCGTTATCCGACGAAGGCAACCCATCATTTAATACGGTATACAAA
ATATCAAAAGCACTGGGTTTGAAACTGCATTTCACTGGAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References