Detailed information of TA system TA233193

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 315892..316545
• Replicon: chromosome
• Accession: NZ_CP091336
• Organism: Acinetobacter baumannii strain AB233-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z41_RS01585
• Protein ID: WP_000607077.1
• Coordinates: 316156..316545 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z41_RS01580
• Protein ID: WP_001288210.1
• Coordinates: 315892..316149 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z41_RS01560 (L2Z41_01560)	311408..312415	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
L2Z41_RS01565 (L2Z41_01565)	312434..312811	+	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z41_RS01570 (L2Z41_01570)	312993..314483	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z41_RS01575 (L2Z41_01575)	314532..315704	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z41_RS01580 (L2Z41_01580)	315892..316149	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z41_RS01585 (L2Z41_01585)	316156..316545	+	390	WP_000607077.1	membrane protein	Toxin
L2Z41_RS01590 (L2Z41_01590)	317315..318400	+	1086	WP_000049106.1	hypothetical protein	-
L2Z41_RS01595 (L2Z41_01595)	318478..319044	+	567	WP_000651538.1	rhombosortase	-
L2Z41_RS01600 (L2Z41_01600)	319232..321427	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233193 WP_000607077.1 NZ_CP091336:316156-316545 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233193 NZ_FO704550:c873143-872940 [Xenorhabdus doucetiae]
ATGACTAAAACTGACTATCTGATGCGTTTGAGAAAATGCACTTCTATTGAGACACTGGAACGTGTAATTGAAAAAAATAA
ATATGAGCTTTCGGCTGATGAACTTGAATTGTTCTACTCCGCAGCTGATCACCGTTTAGCTGAACTGACTATGAATAAAC
TCTATGATAAAATCCCATCATCTGTTTGGAAATTTGTCCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233193 WP_001288210.1 NZ_CP091336:315892-316149 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233193 NZ_FO704550:c873559-873191 [Xenorhabdus doucetiae]
ATGGATGAATATTCACCAAGAAGGCATGATGTTGCTGAATTAAAGTACTTATGTGAAAATTTAATTCATGAGGCGTTTTC
AGTCCTGAATCGCACTGATAATCATTGGATTCACGACCTGACCTCCGAGAAAAGTTTAAAACTAAACGAATTGATTGAAC
ACATTGCAGCTTTTGTCTGGAGTTTTAAAATTAAATACTCAGATAACTACACGCTGAGTACCTTAATTGATAACTATCTA
GATGAAACATATAATTTATTTGGAAGTGATAAGATAAGCTTTCTTGAACTTACAAAATGGCAAAAAACAAACGAACACTT
AACTAACATTCTGTTACATGATTTGAACGCTGCTCTAAGCAAAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7