Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3130474..3131127 Replicon chromosome
Accession NZ_CP091335
Organism Acinetobacter baumannii strain ATCC17978-VUB

Toxin (Protein)


Gene name cptA Uniprot ID A0A1E3M967
Locus tag L2Z42_RS15180 Protein ID WP_009518132.1
Coordinates 3130738..3131127 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z42_RS15175 Protein ID WP_001288210.1
Coordinates 3130474..3130731 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z42_RS15155 (L2Z42_15155) 3125989..3126996 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
L2Z42_RS15160 (L2Z42_15160) 3127015..3127392 + 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z42_RS15165 (L2Z42_15165) 3127574..3129064 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z42_RS15170 (L2Z42_15170) 3129114..3130286 - 1173 WP_001190550.1 acyl-CoA dehydrogenase family protein -
L2Z42_RS15175 (L2Z42_15175) 3130474..3130731 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z42_RS15180 (L2Z42_15180) 3130738..3131127 + 390 WP_009518132.1 hypothetical protein Toxin
L2Z42_RS15185 (L2Z42_15185) 3131897..3132982 + 1086 WP_000049106.1 hypothetical protein -
L2Z42_RS15190 (L2Z42_15190) 3133061..3133627 + 567 WP_000651535.1 rhombosortase -
L2Z42_RS15195 (L2Z42_15195) 3133815..3136010 + 2196 WP_001158904.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15720.03 Da        Isoelectric Point: 10.4623

>T233192 WP_009518132.1 NZ_CP091335:3130738-3131127 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Download         Length: 390 bp

>T233192 NZ_FO704550:c795788-795606 [Xenorhabdus doucetiae]
TTGAACAGTTCAGATTTGATGAGGTTATTAGAAAAAAATGGCTGGAAACTTAAGCGAATTAAAGGGAGCCATCATCAATT
CACTCATCTTGAATTCTCTGTCGTGATAACTGTTCCGCATCCACGTAGAGATATAAAACGAGGAACTCTCAACAAAATCT
TAAAAGATGCAAAGATCAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233192 WP_001288210.1 NZ_CP091335:3130474-3130731 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233192 NZ_FO704550:c795553-795149 [Xenorhabdus doucetiae]
ATGTTATATCCAGCATTTGTCGAAATAGATCAAGATGGTAGCGCCAGTGGTTGGTTCCCTGACGTTGCAGGATGCATCTT
TGCTGGTAACACACTTGAAGAAGCACATTCTGATGCACAATCTGCTATCAATGCACACTTCGAGTTAATGAAAGAGCAAA
ATCTGGAATTCCCATTTCCAAAATCCATGCAAGAGCACCTTGCAGAAAAGGCCGCTGAATACCAAAATGGGCAATGGCTT
TTAATCCCTGTAAATATGAGTCAGTTCGAAGACAAAACAGAGCGCATTAATATTACTCTGCCATTGCGTTTAATTAACCG
TATTGATGCAAAAGTAAAACAGCATCCCGAATATGGCAGCCGCAGTGGATTTTTAGCCTTAGCTGCCCGTAAGGCACTGC
AATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M967

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References