Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 2033990..2034643 Replicon chromosome
Accession NZ_CP091334
Organism Acinetobacter baumannii strain ATCC19606-VUB

Toxin (Protein)


Gene name cptA Uniprot ID D0CD27
Locus tag L2Z43_RS09530 Protein ID WP_000607073.1
Coordinates 2033990..2034379 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z43_RS09535 Protein ID WP_001288210.1
Coordinates 2034386..2034643 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z43_RS09515 (L2Z43_09515) 2029110..2031305 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
L2Z43_RS09520 (L2Z43_09520) 2031493..2032059 - 567 WP_000651536.1 rhombosortase -
L2Z43_RS09525 (L2Z43_09525) 2032138..2033220 - 1083 WP_000049103.1 hypothetical protein -
L2Z43_RS09530 (L2Z43_09530) 2033990..2034379 - 390 WP_000607073.1 membrane protein Toxin
L2Z43_RS09535 (L2Z43_09535) 2034386..2034643 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z43_RS09540 (L2Z43_09540) 2034831..2036003 + 1173 WP_001190553.1 acyl-CoA dehydrogenase family protein -
L2Z43_RS09545 (L2Z43_09545) 2036053..2037543 - 1491 WP_000415127.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z43_RS09550 (L2Z43_09550) 2037725..2038102 - 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z43_RS09555 (L2Z43_09555) 2038121..2039128 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T233189 WP_000607073.1 NZ_CP091334:c2034379-2033990 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233189 NZ_FO704550:c524346-524014 [Xenorhabdus doucetiae]
ATGGTTTCTCGTTTTGTGCCTGATTCTGGCGATATTATTTGGATTGACTTTGATCCTGTGGCTGGACACGAGCAGGGAGG
CCATCGCCCCGCAGTAGTACTGAGTCCATTTGCCTATAACAATAAAGTGGGATTACTGCTCTGTGTTCCTTGCACAACGA
AGGCGAAAGATTATCCTTTTGAAGTTGAATTATCAGGAAGCCGTGACAGTATTGCCTTAGCTGATCAGGTGACATGTGTT
GATTGGCGAGCCAGAAAAGTAACAAAGAAAGGTCATGTTAATTCTTCAGAGCTGGAGGATATAAAGGCTAAAGCCAAGGC
GCTTATCGGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233189 WP_001288210.1 NZ_CP091334:c2034643-2034386 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233189 NZ_FO704550:c524591-524346 [Xenorhabdus doucetiae]
ATGGCACAAGTCGTCGTGAAAAAATGGGGTAACAGCCCTTCTGTACGTCTTCCGGTCGCTATTATGCAAGCCGCCTCACT
AAATGTTGATGATACGGTTGATATTTCTGTCGAAGATGGTCGAATTATCATTATTCCGGTCAAGGCGAAAGAGTATTCTC
TCGATGCGCTATTAGCTGGGATTACACCCGAAAATATTCATGAAAAAATGGATTTTGGTCCTCCAGTGGGTAAGGAATTG
ATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0CD27

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References