Detailed information of TA system TA233188

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1148..1801
• Replicon: chromosome
• Accession: NZ_CP091333
• Organism: Acinetobacter baumannii strain DSM30011-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z44_RS00015
• Protein ID: WP_025469673.1
• Coordinates: 1412..1801 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z44_RS00010
• Protein ID: WP_001288210.1
• Coordinates: 1148..1405 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z44_RS00010 (L2Z44_00010)	1148..1405	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z44_RS00015 (L2Z44_00015)	1412..1801	+	390	WP_025469673.1	membrane protein	Toxin
L2Z44_RS00020 (L2Z44_00020)	2571..3656	+	1086	WP_000049106.1	hypothetical protein	-
L2Z44_RS00025 (L2Z44_00025)	3734..4300	+	567	WP_000651536.1	rhombosortase	-
L2Z44_RS00030 (L2Z44_00030)	4488..6683	+	2196	WP_001158911.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15662.98 Da
• Isoelectric Point: 10.4623

>T233188 WP_025469673.1 NZ_CP091333:1412-1801 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233188 NZ_FO704550:c507455-506967 [Xenorhabdus doucetiae]
ATGGGAATAAATGCACCTGAAATATTAACAGCTGAACATAATATAAATGATTTTTATTGCCAGCATGAAACATTAAACGA
ATGGCTTTCACGCCGGGCGTTAAAAAATAATAAGCTCGGCGCGAGCCGCACCTTTGTGATTTGCAAGGAAGGTACAAAAG
ACGTTATCGGTTATTATTGTCTGAGCGCGGGTTCAATTAATCATATTGAATCTACACCATCGCTTAAACGCAATATGCCA
GATCCTATCCCTGTCGTGCTTCTCGGCCGTCTGGCTGTCGATGTGGAATATCAAGGGAAGAAGTTCGGGGCATTGCTTCT
CCAGGATGCCTGGAAACGTGTCGCCAGCATGGCGGAACAGGTGGGCATTTCAGCTATCATCGTCCACGCACTTGATGAGA
ACGCCCGAACGTTCTATACGCGCCTTGGTTTCACCCAGTCACCGTTGGCACCCTATACGCTGATGCTGCCATTAGGCAGG
AAGAACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233188 WP_001288210.1 NZ_CP091333:1148-1405 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233188 NZ_FO704550:c507718-507446 [Xenorhabdus doucetiae]
ATGAGAACGCAACCTAAAGAAACCCCGATCAATATCCGGGCGAAAGCCTTTCAGCGGGAGCTTATTGATCATGCAGCAAA
CCTGCAATCGAAGACCCGAACTGATTTCATTCTGGATGCTGCCTGCCGCGCAGCCGAAGAGGCGATACTTGCTCAAAACC
ACTTTTTCGTTAACGACGAAAAATATCATGCGTTCATGCAGATGCTGGAACAACCGCTTGCTGATAATGCCGGTTTTAAA
AAACTCATGGGGTATAAAGCACCATGGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7