Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4970537..4971194 Replicon chromosome
Accession NZ_CP091330
Organism Klebsiella pneumoniae strain CRK3022

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L3Y35_RS23940 Protein ID WP_002916310.1
Coordinates 4970784..4971194 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L3Y35_RS23935 Protein ID WP_002916312.1
Coordinates 4970537..4970803 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Y35_RS23910 (4965693) 4965693..4967126 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
L3Y35_RS23915 (4967245) 4967245..4967973 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L3Y35_RS23920 (4968023) 4968023..4968334 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
L3Y35_RS23925 (4968498) 4968498..4969157 + 660 WP_002916317.1 hemolysin III family protein -
L3Y35_RS23930 (4969308) 4969308..4970291 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
L3Y35_RS23935 (4970537) 4970537..4970803 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L3Y35_RS23940 (4970784) 4970784..4971194 + 411 WP_002916310.1 protein YgfX Toxin
L3Y35_RS23945 (4971201) 4971201..4971722 - 522 WP_004144730.1 flavodoxin FldB -
L3Y35_RS23950 (4971823) 4971823..4972719 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L3Y35_RS23955 (4972742) 4972742..4973455 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L3Y35_RS23960 (4973461) 4973461..4975194 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T233183 WP_002916310.1 NZ_CP091330:4970784-4971194 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T233183 NZ_FO082820:c3914236-3914054 [Pseudorhizobium banfieldiae]
ATGGAGCGAAACAGTCAGAAGATTCTCTCCCGCTTGAAACGGGAAGGATTTGAGCTGGTTTCAGTCAAGGGATCTCATCA
CAAGCTGCGGAAGGGGACGGTGACAATCATTGTTCCCCATCCGAAGAAGGATTTGCCGCTGGGCACTGCAAAGGCTATCG
CCAAACAGGCCGGCTGGGTGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT233183 WP_002916312.1 NZ_CP091330:4970537-4970803 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233183 NZ_FO082820:c3914043-3913648 [Pseudorhizobium banfieldiae]
ATGAAGCACTTCATAGCGCTTGTTCACAAGGACCACGACAGCGCCTTCGGCGTCAGCTTCCCCGATCTGCCATCGGTCTT
TTCCGCCGCGGATGGAGAGGATGATCTGGTTGCCAATGCAACGGAGGCGCTGAGGCTCTGGTCGGAAGACGAGGTGTTGC
CGGTACCATCAAGCTATGAAGAGATTGTCTCGCGGGACACCGTCCGAGATGAGTTGGCTCAGGGTGCGTTCCTGATCCGC
GTACCCTTCATAGAGGATGATTCACGCGTCGTGCGGGCGAATGTAACCTTCGAGAAGGGCATGCTGGATGCCATCGACGC
TGCAGCAAGAGAGCGAGGCCTGACTCGCTCGGCGTTTCTCGCGAGTGCCGCCAGAAAAGAGATCGAGGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References