Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4823061..4823902 Replicon chromosome
Accession NZ_CP091330
Organism Klebsiella pneumoniae strain CRK3022

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag L3Y35_RS23185 Protein ID WP_000854822.1
Coordinates 4823519..4823902 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag L3Y35_RS23180 Protein ID WP_053271974.1
Coordinates 4823061..4823429 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Y35_RS23155 (4819115) 4819115..4820479 + 1365 Protein_4523 autotransporter domain-containing protein -
L3Y35_RS23160 (4820806) 4820806..4821624 + 819 WP_001234702.1 DUF932 domain-containing protein -
L3Y35_RS23165 (4821715) 4821715..4822200 + 486 WP_000214317.1 antirestriction protein -
L3Y35_RS23170 (4822215) 4822215..4822691 + 477 WP_001186747.1 RadC family protein -
L3Y35_RS23175 (4822760) 4822760..4822981 + 222 WP_000692312.1 DUF987 domain-containing protein -
L3Y35_RS23180 (4823061) 4823061..4823429 + 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L3Y35_RS23185 (4823519) 4823519..4823902 + 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
L3Y35_RS23190 (4823893) 4823893..4824381 + 489 WP_001177592.1 DUF5983 family protein -
L3Y35_RS23195 (4824348) 4824348..4824590 + 243 WP_166635458.1 DUF957 domain-containing protein -
L3Y35_RS23200 (4824687) 4824687..4825532 + 846 WP_001280435.1 DUF4942 domain-containing protein -
L3Y35_RS23210 (4825831) 4825831..4826337 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
L3Y35_RS23215 (4826437) 4826437..4828278 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T233182 WP_000854822.1 NZ_CP091330:4823519-4823902 [Klebsiella pneumoniae]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T233182 NZ_FO082820:2367028-2367393 [Pseudorhizobium banfieldiae]
ATGATCCGCAGCAACGTGCCGAAGCGCGGCGACGTTTACTGGATCGATCCCAATCCCGTCGCCGGGCGCGAGATGAAGAA
CAGGCATCGCTATGTTGTCATCACCCCGCGCGAGATCAATGCGCTGGGCGTCTCGATGACGGTCCCGATAACGACAGGCG
GAGCCTTCTCGCGCGAAGTCGGTCTCGCTGTTCCGGTGACGGGCCACGACACCACCGGTGTCGCCGTCTGTAACCAGGTG
CGAAGCTTCGACATCCAGGCTCGGATACAGCAGCGGACGGCGCAATACATCGAAACACTGGACGAGGCGACGATGGCGGA
AATCGTTGCCCGGGTCGTCAGTGCTATCGACCCGGAGCCAGCTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT233182 WP_053271974.1 NZ_CP091330:4823061-4823429 [Klebsiella pneumoniae]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT233182 NZ_FO082820:2366768-2367028 [Pseudorhizobium banfieldiae]
ATGACCATCACCACGAAGATCAGGCGACAGGGCGGGGCCGCAGTCGTCACCATCCCGCCGGCGCTCCTGCAGTTGATGCA
GACCCAAGTCGGCGATCAGTTGTCCCTGGTCGTGACCGACGGAGCCCTCGTTGCCCGCCCGGTCCAGGCGGCAAGGAAAC
GGTACACGCTCGGCGAACTGCTGAAAGGATCCGACGAGATGGCTAAACTTGCGGAAACGACACCGCTGGACGGCGATCCC
GTCGGTCGTGAGATCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References