233165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 16605..17193 Replicon plasmid p1
Accession NZ_CP091329
Organism Acinetobacter baumannii strain BM2333

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag L3Q73_RS19840 Protein ID WP_000438827.1
Coordinates 16906..17193 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag L3Q73_RS19835 Protein ID WP_001983304.1
Coordinates 16605..16919 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q73_RS19810 (L3Q73_19810) 12121..12477 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -
L3Q73_RS19815 (L3Q73_19815) 12470..12772 + 303 WP_001129974.1 XRE family transcriptional regulator -
L3Q73_RS19820 (L3Q73_19820) 12765..12974 + 210 WP_000069474.1 hypothetical protein -
L3Q73_RS19825 (L3Q73_19825) 13300..13761 - 462 WP_000761346.1 DIP1984 family protein -
L3Q73_RS19830 (L3Q73_19830) 14066..16477 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
L3Q73_RS19835 (L3Q73_19835) 16605..16919 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
L3Q73_RS19840 (L3Q73_19840) 16906..17193 - 288 WP_000438827.1 BrnT family toxin Toxin
L3Q73_RS19845 (L3Q73_19845) 17461..17760 - 300 WP_000358348.1 hypothetical protein -
L3Q73_RS19850 (L3Q73_19850) 17970..18488 - 519 WP_000839337.1 plasmid replication DNA-binding protein -
L3Q73_RS19855 (L3Q73_19855) 18566..19501 - 936 WP_001292329.1 replication initiation protein RepM -
L3Q73_RS19860 (L3Q73_19860) 20098..21267 - 1170 WP_002134206.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22388 22388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T233165 WP_000438827.1 NZ_CP091329:c17193-16906 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T233165 NZ_CP128548:c4863430-4863137 [Pseudomonas kurunegalensis]
ATGTATCTTGTTGAACAGACGGAGAGCTTTGCAGTTTGGCTATCCAGCTTGAGGGATTTGAAAGCCAAGCTTGCGATAGG
TCGCAGGCTGGAGCGAGTTGCGATAGGCAACCTTGGTGACTTCAAGTGGCTTGGAGGCGGTCTAGGTGAGCTTCGCATCG
ACGTAGGTGCAGGCTATCGCGTCTATTTCACGCAAAAGGGGCACAGATTGGTTCTGCTGCTGGTTGGCGGCGACAAGTCC
ACTCAAGTCGCCGATATTCTCAAATCAAGAAAGCTGCTGAAGGAGATGATATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT233165 WP_001983304.1 NZ_CP091329:c16919-16605 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT233165 NZ_CP128548:c4863140-4862844 [Pseudomonas kurunegalensis]
ATGAGCGAAAAACTGATTCCGTTTGATATGGCAGCTTTGTTGAGTAGCGATGAGGCCATCAGTGAGTACCTTAGCCAGGT
GCTATCAGATGGCGATACCGAAGAGATCATTCGAGCGCTCGGCCATATCGCGCGTGCACGAGGCATGACACACATAGCCA
CGGAGAGTGGTTTGGGCAGAGAAAGCCTCTACAAGGCGCTCAGCCCAGGCGCAAAGCCTCGTTTTGACACTGTGTTGAAG
GTCATTCGAGCCTTGGGGGTAGACCTTCTCGTGCAGCCCCATGCGGTAGCCCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References