233163

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5411..5999 Replicon plasmid p1
Accession NZ_CP091329
Organism Acinetobacter baumannii strain BM2333

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag L3Q73_RS19775 Protein ID WP_000438827.1
Coordinates 5712..5999 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag L3Q73_RS19770 Protein ID WP_001983304.1
Coordinates 5411..5725 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q73_RS19745 (L3Q73_19745) 927..1283 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -
L3Q73_RS19750 (L3Q73_19750) 1276..1578 + 303 WP_001129974.1 XRE family transcriptional regulator -
L3Q73_RS19755 (L3Q73_19755) 1571..1780 + 210 WP_000069474.1 hypothetical protein -
L3Q73_RS19760 (L3Q73_19760) 2106..2567 - 462 WP_000761346.1 DIP1984 family protein -
L3Q73_RS19765 (L3Q73_19765) 2872..5283 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
L3Q73_RS19770 (L3Q73_19770) 5411..5725 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
L3Q73_RS19775 (L3Q73_19775) 5712..5999 - 288 WP_000438827.1 BrnT family toxin Toxin
L3Q73_RS19780 (L3Q73_19780) 6267..6566 - 300 WP_000358348.1 hypothetical protein -
L3Q73_RS19785 (L3Q73_19785) 6683..7444 - 762 WP_000425105.1 hypothetical protein -
L3Q73_RS19790 (L3Q73_19790) 7749..8918 + 1170 WP_002134206.1 MobA/MobL family protein -
L3Q73_RS19795 (L3Q73_19795) 9515..10450 + 936 WP_001292329.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22388 22388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T233163 WP_000438827.1 NZ_CP091329:c5999-5712 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T233163 NZ_CP128548:c4857102-4856812 [Pseudomonas kurunegalensis]
GTGAAGACCATCCTCACAACCGATGATTTCGATGCTTGGTTTTCCAAGCTTAGCGATAAGCGATCTGCGATGCGCATCCA
GGCGCGCATCGACCGTGCCGAAGCAGGGAATTTCGGTGATTGCCAAGCTGTGGGTGAGGGCGTCTCCGAGATGCGTATTC
ACTATGGGCCAGGATATCGTGTGTACTTCACCCAGCGCGGCCTTGAAATCGTGATCCTGCTGGCGGGTGGCGATAAGTCC
ACTCAATCAAAAGACATCAAAACCGCCCTCGACATTGCACGACGGCTTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT233163 WP_001983304.1 NZ_CP091329:c5725-5411 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT233163 NZ_CP128548:c4856802-4856494 [Pseudomonas kurunegalensis]
ATGGGTAACGTCAAGTTGAAAAAATGGGACAGTGCCGAACACCTCAAGACGGACGAGGACATGGCGCTTTACCTCGAAGC
TTGCATTGAAGAGGCGGGTGATGATGCGGCTTTTATCGCCAAGGCGCTCGGCACCATTGCGCGTGCAAAAGGCATGGCTC
AGTTGGCCCGTGATACCGGGCTTGGGCGTGAAAGCCTGTACAAGGCGTTGTCCGGCGAGGGGAACCCAAGCTTCGCCACC
ATCCTGAAGGTGACCAGAGCGCTTGGCCTACAGCTTCATGCTGACGTTGCATCCACTCATACTGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References