Detailed information of TA system TA233156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4596182..4597863
• Replicon: chromosome
• Accession: NZ_CP091326
• Organism: Klebsiella pneumoniae strain hvK2115

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: L3Y29_RS22395
• Protein ID: WP_004146663.1
• Coordinates: 4596946..4597863 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: L3Y29_RS22390
• Protein ID: WP_004177809.1
• Coordinates: 4596182..4596940 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3Y29_RS22375 (4591800)	4591800..4592486	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
L3Y29_RS22380 (4592948)	4592948..4595095	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
L3Y29_RS22385 (4595368)	4595368..4596096	+	729	WP_004177810.1	response regulator transcription factor	-
L3Y29_RS22390 (4596182)	4596182..4596940	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
L3Y29_RS22395 (4596946)	4596946..4597863	+	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
L3Y29_RS22400 (4597988)	4597988..4598995	-	1008	WP_004221949.1	carbohydrate kinase family protein	-
L3Y29_RS22405 (4599070)	4599070..4600011	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
L3Y29_RS22410 (4600042)	4600042..4601040	-	999	WP_004872882.1	ribose ABC transporter permease	-
L3Y29_RS22415 (4601037)	4601037..4602557	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T233156 WP_004146663.1 NZ_CP091326:4596946-4597863 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T233156 NZ_CP128547:3545919-3546101 [Pseudomonas monteilii]
GTGCAAAGCAGGCAGTTGATCAAGGAGCTTGAAGCAGCTGGATGGGTTCTGAAACGTGTCACCGGAAGCCACCACATCTT
CAAGCACCCCAACAACCCAAACTCGATACCAGTGCCACACCCCAAAAAGGATCTACCAATCGGCACGGTAAAGAGCATCA
AGGAACGAGCCGGGTTGAAATAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT233156 WP_004177809.1 NZ_CP091326:4596182-4596940 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT233156 NZ_CP128547:3546139-3546540 [Pseudomonas monteilii]
ATGCAATACCCAATCTGCATCGAATGGGGCGACGAGAACACCGCCACCGGCATCCAGATCCCTGATATTCCAGGCGCTGT
AACTGCGGGCGACACCTTCGAGGAGGCATATTCCTCCGCTGTCGAGGTCGCTCATATCATGCTGGAAGAGATCGCAAGCA
ACGGCCAGGCCATCCCAATGCCAACCAGCGCAGCAGCGCACCGAGGTAATCCTGACTTCGCTGATATGGGCTGGGGAATG
CTGGAAATCGACATCACCCCGTACCTGGGGAAAACCGAGAAGGTCAACGTTACCCTGCCGGGCTTTGTGATCCAGCAAAT
TGACCGGTACGTGCGAGATCACAACGTCAAGAGCCGTTCATCTTTCCTGGCTGATGCTGCCATGGAAAAGCTGGGCCGCT
GA

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05