Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3393827..3394484 Replicon chromosome
Accession NZ_CP091326
Organism Klebsiella pneumoniae strain hvK2115

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L3Y29_RS16585 Protein ID WP_002916310.1
Coordinates 3393827..3394237 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L3Y29_RS16590 Protein ID WP_002916312.1
Coordinates 3394218..3394484 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Y29_RS16565 (3389827) 3389827..3391560 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
L3Y29_RS16570 (3391566) 3391566..3392279 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L3Y29_RS16575 (3392302) 3392302..3393198 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L3Y29_RS16580 (3393299) 3393299..3393820 + 522 WP_002916308.1 flavodoxin FldB -
L3Y29_RS16585 (3393827) 3393827..3394237 - 411 WP_002916310.1 protein YgfX Toxin
L3Y29_RS16590 (3394218) 3394218..3394484 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L3Y29_RS16595 (3394730) 3394730..3395713 + 984 WP_159147087.1 tRNA-modifying protein YgfZ -
L3Y29_RS16600 (3395812) 3395812..3396471 - 660 WP_002916317.1 hemolysin III family protein -
L3Y29_RS16605 (3396635) 3396635..3396946 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
L3Y29_RS16610 (3396996) 3396996..3397724 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L3Y29_RS16615 (3397843) 3397843..3399276 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T233151 WP_002916310.1 NZ_CP091326:c3394237-3393827 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T233151 NZ_CP128545:3517595-3517777 [Pseudomonas monteilii]
GTGCAAAGCAGGCAGTTGATCAAGGAGCTTGAAGCAGCTGGATGGGTTCTGAAACGTGTCACCGGAAGCCACCACATCTT
CAAGCACCCCAACAACCCAAACTCGATACCAGTGCCACACCCCAAAAAGGATCTACCAATCGGCACGGTAAAGAGCATCA
AGGAACGAGCCGGGTTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT233151 WP_002916312.1 NZ_CP091326:c3394484-3394218 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233151 NZ_CP128545:3517815-3518216 [Pseudomonas monteilii]
ATGCAATACCCAATCTGCATCGAATGGGGCGACGAGAACACCGCCACCGGCATCCAGATCCCTGATATTCCAGGCGCTGT
AACTGCGGGCGACACCTTCGAGGAGGCATATTCCTCCGCTGTCGAGGTCGCTCATATCATGCTGGAAGAGATCGCAAGCA
ACGGCCAGGCCATCCCAATGCCAACCAGCGCAGCAGCGCACCGAGGTAATCCTGACTTCGCTGATATGGGCTGGGGAATG
CTGGAAATCGACATCACCCCGTACCTGGGGAAAACCGAGAAGGTCAACGTTACCCTGCCGGGCTTTGTGATCCAGCAAAT
TGACCGGTACGTGCGAGATCACAACGTCAAGAGCCGTTCATCTTTCCTGGCTGATGCTGCCATGGAAAAGCTGGGCCGCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References