Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3151143..3151719 Replicon chromosome
Accession NC_011740
Organism Escherichia fergusonii ATCC 35469

Toxin (Protein)


Gene name shpA Uniprot ID A0A7W3EF74
Locus tag EFER_RS15510 Protein ID WP_024256534.1
Coordinates 3151432..3151719 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A7U9DAW4
Locus tag EFER_RS15505 Protein ID WP_000063150.1
Coordinates 3151143..3151445 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFER_RS15480 3146957..3147469 + 513 WP_001175455.1 4-hydroxyphenylacetate 3-monooxygenase reductase subunit -
EFER_RS15490 3147739..3149889 + 2151 WP_001314407.1 pyruvate/proton symporter BtsT -
EFER_RS15495 3149939..3150142 + 204 WP_000467859.1 YbdD/YjiX family protein -
EFER_RS15500 3150153..3151109 + 957 WP_001297640.1 GTPase -
EFER_RS15505 3151143..3151445 - 303 WP_000063150.1 BrnA antitoxin family protein Antitoxin
EFER_RS15510 3151432..3151719 - 288 WP_024256534.1 BrnT family toxin Toxin
EFER_RS15515 3151875..3152609 - 735 WP_000208601.1 Fic family protein -
EFER_RS15520 3152872..3156384 + 3513 WP_000981386.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11241.74 Da        Isoelectric Point: 7.4020

>T23314 WP_024256534.1 NC_011740:c3151719-3151432 [Escherichia fergusonii ATCC 35469]
MPMEFEWDANKAKSNRMKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T23314 NC_011740:c3151719-3151432 [Escherichia fergusonii ATCC 35469]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGATGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11532.03 Da        Isoelectric Point: 9.4646

>AT23314 WP_000063150.1 NC_011740:c3151445-3151143 [Escherichia fergusonii ATCC 35469]
MSMVKHKRGTPSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT23314 NC_011740:c3151445-3151143 [Escherichia fergusonii ATCC 35469]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
CAAATCCGACGAGGATATTGATTACAGCGACATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAATAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3EF74

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAW4

References