Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3737134..3737791 Replicon chromosome
Accession NZ_CP091319
Organism Enterobacter sp. JH25

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag L2Y28_RS17885 Protein ID WP_022649305.1
Coordinates 3737134..3737544 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag L2Y28_RS17890 Protein ID WP_003863437.1
Coordinates 3737525..3737791 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y28_RS17865 3733132..3734865 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
L2Y28_RS17870 3734871..3735584 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L2Y28_RS17875 3735613..3736509 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
L2Y28_RS17880 3736611..3737132 + 522 WP_015571793.1 flavodoxin FldB -
L2Y28_RS17885 3737134..3737544 - 411 WP_022649305.1 protein YgfX Toxin
L2Y28_RS17890 3737525..3737791 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
L2Y28_RS17895 3738086..3739066 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
L2Y28_RS17900 3739590..3740249 - 660 WP_022649307.1 hemolysin III family protein -
L2Y28_RS17905 3740516..3741247 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T233135 WP_022649305.1 NZ_CP091319:c3737544-3737134 [Enterobacter sp. JH25]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T233135 NZ_CP128541:3840449-3840631 [Pseudomonas monteilii]
GTGCAAAGCAGGCAGTTGATCAAGGAGCTTGAAGCCGCTGGATGGGTTCTGAAACGAGTGACTGGAAGCCACCACATCTT
CAAACACCCCAACAACCCAAACTCGATACCAGTGCCACACCCCAAAAAGGATCTACCGATCGGCACGGTAAAGAGCATCA
AGGAACGAGCCGGGTTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT233135 WP_003863437.1 NZ_CP091319:c3737791-3737525 [Enterobacter sp. JH25]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT233135 NZ_CP128541:3840669-3841070 [Pseudomonas monteilii]
ATGCAATACCCAATCTGCATCGAATGGGGCGACGAGAACACCGCTACCGGCATTCAGATCCCCGATATTCCAGGCGCCGT
CACAGCAGGCGACACCTTCGAGGAGGCCTATACTTCGGCCGTCGAAGTTGCCCACATCATGCTGGAAGAGATCGCCAGCA
ATGGCCAGGACATCCCAATGCCAACTAGCGCCGCGGCACACCGGGGTAATCCAGACTTCGCCGACATGGGCTGGGGCATG
CTGGAGATCGACATTACGCCCTACCTGGGCAAGACAGAGAAGGTCAATGTCACCCTGCCTGGCTTCGTCATTCAGCAGAT
CGACCGGTACGTTCGCGATCACAACGTGAAGAGTCGGTCGTCGTTCTTGGCTGATGCCGCCATGGAAAAGTTGGGACGGT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References