Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3470396..3471135 Replicon chromosome
Accession NZ_CP091319
Organism Enterobacter sp. JH25

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag L2Y28_RS16610 Protein ID WP_022649088.1
Coordinates 3470755..3471135 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag L2Y28_RS16605 Protein ID WP_022649087.1
Coordinates 3470396..3470722 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y28_RS16590 3466290..3468950 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
L2Y28_RS16595 3469580..3469903 + 324 WP_022649085.1 antirestriction protein -
L2Y28_RS16600 3469918..3470385 + 468 WP_022649086.1 DNA repair protein RadC -
L2Y28_RS16605 3470396..3470722 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L2Y28_RS16610 3470755..3471135 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
L2Y28_RS16615 3471132..3471359 + 228 WP_022649089.1 DUF5983 family protein -
L2Y28_RS16620 3471751..3472044 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
L2Y28_RS16625 3472388..3473704 - 1317 WP_022649091.1 amidase family protein -
L2Y28_RS16630 3473759..3475054 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3435608..3472044 36436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T233134 WP_022649088.1 NZ_CP091319:3470755-3471135 [Enterobacter sp. JH25]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T233134 NZ_CP128541:3614270-3614452 [Pseudomonas monteilii]
GTGCAAAGCAGGCAGTTGATCAAGGAGCTTGAAGCAGCTGGATGGGTTCTGAAACGTGTCACCGGAAGCCACCACATCTT
CAAGCACCCCAACAACCCAAACTCGATACCAGTGCCACACCCCAAAAAGGATCTACCAATCGGCACGGTAAAGAGCATCA
AGGAACGAGCCGGGTTGAAATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT233134 WP_022649087.1 NZ_CP091319:3470396-3470722 [Enterobacter sp. JH25]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT233134 NZ_CP128541:3614490-3614891 [Pseudomonas monteilii]
ATGCAATACCCAATCTGCATCGAATGGGGCGACGAGAACACCGCCACCGGCATCCAGATCCCTGATATTCCAGGCGCTGT
AACTGCGGGCGACACCTTCGAGGAGGCATATTCCTCCGCTGTCGAGGTCGCTCATATCATGCTGGAAGAGATCGCAAGCA
ACGGCCAGGCCATCCCAATGCCAACCAGCGCAGCAGCGCACCGAGGTAATCCTGACTTCGCTGATATGGGCTGGGGAATG
CTGGAAATCGACATCACCCCGTACCTGGGGAAAACCGAGAAGGTCAACGTTACCCTGCCGGGCTTTGTGATCCAGCAAAT
TGACCGGTACGTGCGAGATCACAACGTCAAGAGCCGTTCATCTTTCCTGGCTGATGCTGCCATGGAAAAGCTGGGCCGCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References